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- W94690679 abstract "This work has studied the spatially heterogeneous nature of ultrafiltration hollow fiber bioreactors used for immobilized mammalian cell culture. In reactors operated with unidirectional medium recycle flow, downstream concentration of high molecular weight proteins and cells in the immobilized phase have been measured. Mechanisms responsible for these phenomena have been investigated, and their implications in process design and operation considered. The heterogeneous protein and cell distributions in ultrafiltration hollow fiber bioreactors were reduced by periodic alternation of recycle flow direction and the reactor productivity was doubled." @default.
- W94690679 created "2016-06-24" @default.
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- W94690679 date "1991-01-01" @default.
- W94690679 modified "2023-10-18" @default.
- W94690679 title "HYBRIDOMA, ANTIBODY AND GROWTH FACTOR DISTRIBUTIONS IN THE SHELL-SIDE OF ULTRAFILTRATION HOLLOW FIBER BIOREACTORS" @default.
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- W94690679 doi "https://doi.org/10.1016/b978-0-7506-1103-9.50086-x" @default.
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