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- W946918322 abstract "This chapter provides specific examples of the use of nonlinear regression analysis to resolve signals in multicomponent analyses. It begins with the discussion of resolution of chromatographic peaks with single-channel detection, including examples from high-pressure liquid chromatography and high performance size-exclusion chromatography. Furthermore, this chapter turns to the discussion of powerful and information-rich multichannel methods characteristic of chromatography coupled with detection by mass, infrared or UV–VIS detection. This chapter also deals with multicomponent time-resolved fluorescence, which is representative of any time resolved spectroscopic method. In single channel chromatography, the effluent from the column passes through a single detector and the output of the analysis is the response of the detector vs. Time. Conventional spectrophotometric analysis measures the signal as dependent variable vs. wavelength or energy as the independent variable. Addition of a second independent variable in the detection system, such as time greatly increases the information available for each component in a mixture. This is called multichannel or multivariate detection." @default.
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- W946918322 date "1996-01-01" @default.
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- W946918322 title "Chromatography and Multichannel Detection Methods" @default.
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- W946918322 doi "https://doi.org/10.1016/b978-012604490-4/50015-x" @default.
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