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- W94743663 abstract "Fc receptors for IgG (FcγRs) and soluble Ig-binding factors play important roles in immunity. These roles can be grouped into three areas: (1) cellular immune defense and lymphocyte regulation, (2) immunoglobulin transcytosis, and (3) autoimmune pathology. In cellular immune defense, upon cross-linking by IgG aggregates, FcγRs activate a variety of leukocyte responses—such as phagocytosis, antibody-dependent cell cytotoxicity (ADCC) and release of lysosomal hydrolases, reactive oxygen metabolites, arachidonate metabolites, and other mediators of inflammation. Soluble immunoglobulin-binding factors (IBFs) and cross-linking of cell-surface antibodies to membrane-bound FcγRs inhibit β cell differentiation. All FcRs, except CD23 (FcγRII), are members of the Ig supergene family and are homologous to each other. Most FcγRs are type I membrane glycoproteins with one transmembrane domain and a cytoplasmic domain. However, huFcγRIII-l is anchored in the neutrophil plasma membrane by a glycan phosphatidylinositol moiety. Low-avidity forms of membrane-bound FcγRs contain two extracellular Ig-like regions, whereas high-avidity forms contain three Ig-like regions. Assigning functions to individual FcγRs has been a challenging task because many share immunologically indistinguishable extracellular domains, within a subclass, and their cellular distributions overlap considerably. This chapter reviews the current state of knowledge of the structure, function, and signaling mechanisms of mouse and human Fcγ receptors." @default.
- W94743663 created "2016-06-24" @default.
- W94743663 creator A5009182652 @default.
- W94743663 creator A5047944765 @default.
- W94743663 creator A5085300497 @default.
- W94743663 date "1990-01-01" @default.
- W94743663 modified "2023-09-24" @default.
- W94743663 title "Fcγ Receptors: A Diverse and Multifunctional Gene Family" @default.
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