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- W947876544 abstract "Publisher Summary This chapter discusses the β-phenethylamines. After the determination of the structure of the adrenaline molecule and the discovery of tyramine in putrefied meat and ergot much interest was aroused in compounds of similar chemical constitution. Shortly afterwards, Barger and Dale examined pharmacologically a large series of amines, structurally related to adrenaline and tyramine. The basic skeleton of the adrenaline molecule is that of a β-phenethylamine. There is a general agreement that the natural phenethylamines are biogenetically linked to the naturally occurring aromatic amino acids, such as phenylalanine, tyrosine, N-methyltyrosine and 3:4 dihydroxyphenylalanine (dopa). This derivation involves only very simple and biologically plausible reactions, such as decarboxylation, oxidation, and O - and N -methylation. Naturally occurring β-phenethylamines may have been formed by biological decarboxylation of the protein amino acids, phenylalanine, and tyrosine." @default.
- W947876544 created "2016-06-24" @default.
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- W947876544 date "1953-01-01" @default.
- W947876544 modified "2023-09-27" @default.
- W947876544 title "Chapter 22 β-Phenethylamines" @default.
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- W947876544 doi "https://doi.org/10.1016/s1876-0813(08)60144-x" @default.
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