Matches in SemOpenAlex for { <https://semopenalex.org/work/W948187860> ?p ?o ?g. }
- W948187860 endingPage "45" @default.
- W948187860 startingPage "33" @default.
- W948187860 abstract "Over the last few years the distinction between naturally occurring and abnormal neuronal cell death mechanisms has become less clear. Not only have stress-related pathways been implicated in developmental programmed cell death, but neuronal loss in human neuro-degenerative disease or stroke has been shown to use some of the same mechanisms as classical apoptosis. The Fas receptor is a “killer molecule” most studied in the immune system. We review here some of the findings concerning its roles in neurons, focussing on results from our laboratory and from others concerning spinal motoneurons. There is now evidence that Fas activation is involved in certain forms of neuronal death, and that this process can be tightly controlled. It is too early to determine the precise role of Fas in the nervous system, either during development or in pathological situations. However, the existence of novel signalling pathways upstream and downstream of Fas in neurons suggests that, if Fas activation does contribute to loss of neurons in human patients, Fas-related pathways may provide a promising new set of targets for therapeutical intervention." @default.
- W948187860 created "2016-06-24" @default.
- W948187860 creator A5004386868 @default.
- W948187860 creator A5022722962 @default.
- W948187860 creator A5030241844 @default.
- W948187860 creator A5084828657 @default.
- W948187860 creator A5086146393 @default.
- W948187860 date "2001-01-01" @default.
- W948187860 modified "2023-09-26" @default.
- W948187860 title "Roles for Fas in Programmed Cell Death of Motoneurons" @default.
- W948187860 cites W1488489148 @default.
- W948187860 cites W1615638781 @default.
- W948187860 cites W1618426198 @default.
- W948187860 cites W1829813323 @default.
- W948187860 cites W1965299119 @default.
- W948187860 cites W1967814428 @default.
- W948187860 cites W1973577899 @default.
- W948187860 cites W1974899939 @default.
- W948187860 cites W1984684782 @default.
- W948187860 cites W1985442766 @default.
- W948187860 cites W1986308149 @default.
- W948187860 cites W1988099244 @default.
- W948187860 cites W1992060545 @default.
- W948187860 cites W1998038367 @default.
- W948187860 cites W2002503549 @default.
- W948187860 cites W2004645606 @default.
- W948187860 cites W2005770035 @default.
- W948187860 cites W2008597649 @default.
- W948187860 cites W2009705816 @default.
- W948187860 cites W2012173926 @default.
- W948187860 cites W2012357103 @default.
- W948187860 cites W2019250475 @default.
- W948187860 cites W2021033472 @default.
- W948187860 cites W2021359548 @default.
- W948187860 cites W2028111124 @default.
- W948187860 cites W2033828028 @default.
- W948187860 cites W2034184306 @default.
- W948187860 cites W2039355845 @default.
- W948187860 cites W2040744282 @default.
- W948187860 cites W2041090790 @default.
- W948187860 cites W2041466047 @default.
- W948187860 cites W2050120071 @default.
- W948187860 cites W2055149392 @default.
- W948187860 cites W2060982272 @default.
- W948187860 cites W2062853648 @default.
- W948187860 cites W2064122617 @default.
- W948187860 cites W2065413461 @default.
- W948187860 cites W2073028327 @default.
- W948187860 cites W2086313080 @default.
- W948187860 cites W2086689324 @default.
- W948187860 cites W2087339935 @default.
- W948187860 cites W2094155854 @default.
- W948187860 cites W2094334993 @default.
- W948187860 cites W2097767970 @default.
- W948187860 cites W2111125738 @default.
- W948187860 cites W2127789417 @default.
- W948187860 cites W2136269288 @default.
- W948187860 cites W2137035181 @default.
- W948187860 cites W2144011146 @default.
- W948187860 cites W2146346171 @default.
- W948187860 cites W2154745705 @default.
- W948187860 cites W2156945415 @default.
- W948187860 cites W2157023326 @default.
- W948187860 cites W2157047802 @default.
- W948187860 cites W4300983316 @default.
- W948187860 doi "https://doi.org/10.1007/978-3-662-04333-2_4" @default.
- W948187860 hasPublicationYear "2001" @default.
- W948187860 type Work @default.
- W948187860 sameAs 948187860 @default.
- W948187860 citedByCount "0" @default.
- W948187860 crossrefType "book-chapter" @default.
- W948187860 hasAuthorship W948187860A5004386868 @default.
- W948187860 hasAuthorship W948187860A5022722962 @default.
- W948187860 hasAuthorship W948187860A5030241844 @default.
- W948187860 hasAuthorship W948187860A5084828657 @default.
- W948187860 hasAuthorship W948187860A5086146393 @default.
- W948187860 hasConcept C169760540 @default.
- W948187860 hasConcept C170493617 @default.
- W948187860 hasConcept C190283241 @default.
- W948187860 hasConcept C203014093 @default.
- W948187860 hasConcept C2778794669 @default.
- W948187860 hasConcept C3031857 @default.
- W948187860 hasConcept C31573885 @default.
- W948187860 hasConcept C54355233 @default.
- W948187860 hasConcept C545706735 @default.
- W948187860 hasConcept C66008609 @default.
- W948187860 hasConcept C86803240 @default.
- W948187860 hasConcept C8891405 @default.
- W948187860 hasConcept C95444343 @default.
- W948187860 hasConceptScore W948187860C169760540 @default.
- W948187860 hasConceptScore W948187860C170493617 @default.
- W948187860 hasConceptScore W948187860C190283241 @default.
- W948187860 hasConceptScore W948187860C203014093 @default.
- W948187860 hasConceptScore W948187860C2778794669 @default.
- W948187860 hasConceptScore W948187860C3031857 @default.
- W948187860 hasConceptScore W948187860C31573885 @default.
- W948187860 hasConceptScore W948187860C54355233 @default.
- W948187860 hasConceptScore W948187860C545706735 @default.