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- W948225845 abstract "Aim. The aim of this study was to investigate virulent properties of the genus Candida spp. in patients with persistent bronchial asthma and long-term treatment with inhaled steroids. Methods. In this study, virulent properties of the genus Candida spp. were investigated in oropharyngeal smears of 30 patients with persistent asthma treated with moderate-to-high dose inhaled corticosteroids (ICS) for at least 1 year. A control group included 15 steroid-naive asthmatic patients. Fungi were identified by conventional methods (morphology, presence of germination tubes, chlamydospores, fermentation of carbohydrates). Sensitivity to antibiotics was determined by disk method on the Saburo agar medium. Adhesion was assessed in a model with nitrocellulose film and immobilized hemoglobin. Proteinase activity was measured by the ELISA method in supernatant at two pH values: acidic (pH = 4.5) or weakly alkaline (pH = 7.8). CD cell leukocyte receptor proteolysis was evaluated by the cytofluorometrics method. Results. An incidence of fungal colonization of the pharynx in ICS-treated patients with bronchial asthma was 76.7 %. Most strains were highly virulent as they had significantly higher adhesive and enzymatic activity and multi-drug resistance to antifungals compared to control group. Conclusion. The ability of these strains to secrete proteolytic enzymes against CD4+ T-lymphocyte surface receptors could provide an additional immunomodulatory mechanism in Candida albicans invasion." @default.
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- W948225845 date "2014-01-01" @default.
- W948225845 modified "2023-10-12" @default.
- W948225845 title "VIRULENT PROPERTIES OF GENUS CANDIDA IN PATIENTS WITH PERSISTENT BRONCHIAL ASTHMA AND LONG-TERM TREATMENT WITH INHALED STEROIDS" @default.
- W948225845 doi "https://doi.org/10.18093/0869-0189-2014-0-3-73-77" @default.
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