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- W94832779 abstract "SUMMARY. A simple, sensitive and reproducible RP-HPLC method was developed and validated for thesimultaneous determination of atorvastatin and gemfibrozil in human plasma. After a single step liquid-liquid extraction of both the drugs with acetonitrile, the separation was accomplished on a Merck C 18column (250 x 4.6, 5 μm). Diode array detection at a wavelength of 240 nm was carried out with a mobilephase comprising of a mixture of 0.1M ammonium acetate buffer (pH 5.0) and acetonitrile in the ratio of(45:55, v/v). The method was linear in the concentration range of 0.1-20 μg/ml for atorvastatin and 6-1200μg/ml for gemfibrozil with correlation coefficient between 0.9997 and 0.9976. The limit of detection was0.03 μg/ml for atorvastatin and 1.8 μg/ml for gemfibrozil. The limit of quantitation was 0.1 μg/ml for ator-vastatin and 6 μg/ml for gemfibrozil. The average recovery of both the analytes was greater than 75 %.The method was validated in terms of linearity, recovery, precision, specificity, LOD/LOQ values and sta-bility of solutions and it was applied successfully for the determination of atorvastatin and gemfibrozil inspiked human plasma." @default.
- W94832779 created "2016-06-24" @default.
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- W94832779 date "2010-01-01" @default.
- W94832779 modified "2023-09-23" @default.
- W94832779 title "Determination of Atorvastatin and Gemfibrozil in Human Plasma by Reversed-Phase Liquid Chromatography" @default.
- W94832779 hasPublicationYear "2010" @default.
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