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- W948533478 abstract "1881 Objectives Respiratory motion during PET/CT scan causes inaccuracies in measurement of FDG uptake of lung lesions. This study was designed to compare FDG uptake of lung nodules in 20-s breath-hold (BH) PET/CT and free-breathing (FB) PET/CT with the histological findings. Methods We studied 89 patients with lung nodules who underwent clinical FB PET/CT, followed by deep-inspiration BH PET/CT of the thorax. In BH PET/CT, the patients were asked to hold their breath in deep inspiration for 10 s of the CT scan and for 20 s of the PET scan. FDG uptake of the nodule (SUVmax) was measured in FB PET and BH PET, and the percentage difference between these two values (%Diff-SUV) was calculated. The histological results of the 89 patients were squamous cell carcinoma (SCC) in 24 patients, adenocarcinoma without bronchioloalveolar carcinoma (BAC) in 20, adenocarcinoma with BAC in 30 and benign granuloma in 15. Results In FB PET, mean SUVmax of SCC, adenocarcinoma without BAC, adenocarcinoma with BAC and granuloma were 11.98 ± 6.65, 9.77 ± 3.73, 2.95 ± 1.95 and 3.18 ± 1.94, respectively. These values of BH PET were 15.59 ± 8.02, 12.29 ± 4.59, 4.14 ± 2.93 and 4.17 ± 2.70, respectively. As compared with FB PET, BH PET showed an increase in SUVmax by 34.6% (mean %Diff-SUV). In BH PET, SCC and adenocarcinoma without BAC had significantly higher SUVmax than adenocarcinoma with BAC and granuloma (p Conclusions Although BH PET/CT reduced breathing-induced target blurring and thus increased FDG uptake of lung nodules, there was a lack of additional values for the differential diagnosis, when compared to FB PET/CT. BH PET/CT may be more useful for therapy monitoring rather than the diagnosis of lung nodules" @default.
- W948533478 created "2016-06-24" @default.
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- W948533478 date "2011-05-01" @default.
- W948533478 modified "2023-09-28" @default.
- W948533478 title "Value of 20-s acquisition of deep-inspiration breath-hold PET/CT for diagnosis of lung nodules" @default.
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