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- W948550917 endingPage "414" @default.
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- W948550917 abstract "This chapter presents an overview of PC12 pheochromocytoma cultures in neurobiological research. The PC12 line of rat pheochromocytoma cells promises to be highly useful for studying both chromaffin cells and neurons and, consequently, has been employed in an increasing number of laboratories. PC12 cells propagated in vivo or in culture without nerve-growth factor are readily classifiable as pheochromocytomas by current morphological and chemical criteria. They have no processes and are characterized by numerous secretory granules ranging in diameter up to 350 nm. They also contain total catecholamine stores comparable to those in rat adrenal glands and show intense formaldehyde-induced fluorescence. In addition to catecholamines, PC12 cells contain several other secretory products, some of which have also been reported in human pheochromocytomas. The morphology of the cells and their synthesis, storage, release, and uptake of neurohumoral or neurotransmitter substances can be modulated in a number of ways within the overall chromaffin cell-like phenotype. This chapter reviews the currently known properties of the PC12 line. It also discusses the ways in which it has been and could be exploited to increase the knowledge of neuronal and neurosecretory cells." @default.
- W948550917 created "2016-06-24" @default.
- W948550917 creator A5009606299 @default.
- W948550917 creator A5050331720 @default.
- W948550917 date "1982-01-01" @default.
- W948550917 modified "2023-10-16" @default.
- W948550917 title "PC12 Pheochromocytoma Cultures in Neurobiological Research" @default.
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