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- W948617513 endingPage "936" @default.
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- W948617513 abstract "Osteoarthritis occurs in the majority of adults and is often described as “wear and tear” arthritis, or a disease of aging resulting from the structural and biochemical breakdown of articular cartilage in synovial joints. The causes of degenerative osteoarthritis with aging are complex and involve interrelated biological, mechanical, and structural pathways. This chapter examines the interrelationship or coupling of these pathways that converges at an in vivo systems level in humans. Using the knee as an example, an integrated in vivo framework for understanding the various factors that influence the initiation and progression of osteoarthritis is described. This framework provides a basis for explaining the role of kinematics and load on the progression of osteoarthritis. The framework helps to explain the integrated effect of biological, morphological, and neuromuscular changes to the musculoskeletal system during aging or during menopause on the increased rate of idiopathic osteoarthritis with aging." @default.
- W948617513 created "2016-06-24" @default.
- W948617513 creator A5045021131 @default.
- W948617513 creator A5059142743 @default.
- W948617513 date "2006-01-01" @default.
- W948617513 modified "2023-10-18" @default.
- W948617513 title "A Model for Understanding the Pathomechanics of Osteoarthritis in Aging" @default.
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