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- W948677896 abstract "Liposomes are three-dimensional lipid structure with a closed boundary in which an aqueous microenvironment is separated from an outside. They have been considered as suitable vectors for intracytoplasmic delivery of drugs and macromolecules like proteins and nucleic acids into cells. Ribosome inactivating proteins (RIPs) are enzymes of plant origin, which inhibit protein synthesis by catalitically inactivating ribosomes. Interest in RIPs include their use as abortifacients, toxic components of immunotoxins targeted at malignant cell and antiviral agents, both through transgenic expression in plants and as anti-HIV agents in AIDS patients [1]. Luffin and saporin are positively charged at physiological pH; the interaction of these enzymes with negatively charged phospholipid vesicles results in the passage of proteins through the lipid bilayers. The resulting liposomes are carriers that can deliver type 1 RIPs inside cells. This system has been applied to the treatment of human melanoma in situ [2]. Moreover the encapsulation of labelled RIPs into unilamellar vesicles could be used as an easy, uninvasive way to follow the intracellular dynamics of the toxins [3]." @default.
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- W948677896 date "2000-01-01" @default.
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- W948677896 title "Liposomes containing plant ribosome-inactivating proteins." @default.
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