Matches in SemOpenAlex for { <https://semopenalex.org/work/W94911976> ?p ?o ?g. }
- W94911976 endingPage "873" @default.
- W94911976 startingPage "865" @default.
- W94911976 abstract "Intravenous immunoglobulin (IVIG)–resistant Kawasaki disease (KD) patients comprise at least 20% of treated patients and are at high risk for coronary artery abnormalities. If identified early in the course of the disease, such patients may benefit from additional anti-inflammatory therapy. The aim of this study was to compare the transcript abundance between IVIG resistant and -responsive KD patients, to identify biomarkers that might differentiate between these two groups and to generate new targets for therapies in IVIG resistant KD patients. We compared the transcript abundance profiles of whole-blood RNA on Agilent arrays from acute and convalescent KD subjects and age-similar, healthy controls. KD subjects were stratified as IVIG resistant or –responsive based on response to initial IVIG therapy. Transcript abundance was higher for IL-1 pathway genes (IL-1 receptor, interleukin receptor associated kinase, p38 mitogen-activated protein kinase), and MMP-8. These findings point to candidate biomarkers that may predict IVIG resistance in acute KD patients. The results also underscore the importance of the IL-1 pathway as a mediator of inflammation in KD and suggest that IL-1 or its receptor may be reasonable targets for therapy, particularly for IVIG resistant patients." @default.
- W94911976 created "2016-06-24" @default.
- W94911976 creator A5008977601 @default.
- W94911976 creator A5014018897 @default.
- W94911976 creator A5017134095 @default.
- W94911976 creator A5032531829 @default.
- W94911976 creator A5037514446 @default.
- W94911976 creator A5038455658 @default.
- W94911976 creator A5041295779 @default.
- W94911976 creator A5061845242 @default.
- W94911976 creator A5065297743 @default.
- W94911976 creator A5065492245 @default.
- W94911976 creator A5088917579 @default.
- W94911976 creator A5091218113 @default.
- W94911976 date "2010-09-01" @default.
- W94911976 modified "2023-10-18" @default.
- W94911976 title "Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance" @default.
- W94911976 cites W1518010828 @default.
- W94911976 cites W1569555874 @default.
- W94911976 cites W1774714795 @default.
- W94911976 cites W1945593336 @default.
- W94911976 cites W1963550372 @default.
- W94911976 cites W1963598954 @default.
- W94911976 cites W1966947841 @default.
- W94911976 cites W1969318919 @default.
- W94911976 cites W1973614704 @default.
- W94911976 cites W1976975154 @default.
- W94911976 cites W1977884267 @default.
- W94911976 cites W1985768272 @default.
- W94911976 cites W1990350564 @default.
- W94911976 cites W1993549868 @default.
- W94911976 cites W1999377902 @default.
- W94911976 cites W2000728841 @default.
- W94911976 cites W2002838180 @default.
- W94911976 cites W2004612583 @default.
- W94911976 cites W2007133051 @default.
- W94911976 cites W2009448247 @default.
- W94911976 cites W2013841086 @default.
- W94911976 cites W2020577123 @default.
- W94911976 cites W2021303849 @default.
- W94911976 cites W2034487954 @default.
- W94911976 cites W2041755747 @default.
- W94911976 cites W2042436371 @default.
- W94911976 cites W2043266381 @default.
- W94911976 cites W2047981010 @default.
- W94911976 cites W2053452881 @default.
- W94911976 cites W2054384691 @default.
- W94911976 cites W2054538838 @default.
- W94911976 cites W2056201230 @default.
- W94911976 cites W2065613854 @default.
- W94911976 cites W2071347890 @default.
- W94911976 cites W2115867185 @default.
- W94911976 cites W2119737077 @default.
- W94911976 cites W2120009840 @default.
- W94911976 cites W2121482945 @default.
- W94911976 cites W2125203203 @default.
- W94911976 cites W2149374693 @default.
- W94911976 cites W2161006854 @default.
- W94911976 cites W2164628639 @default.
- W94911976 cites W2217481046 @default.
- W94911976 cites W2315160100 @default.
- W94911976 cites W2410862888 @default.
- W94911976 doi "https://doi.org/10.1016/j.humimm.2010.06.008" @default.
- W94911976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2929310" @default.
- W94911976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20600450" @default.
- W94911976 hasPublicationYear "2010" @default.
- W94911976 type Work @default.
- W94911976 sameAs 94911976 @default.
- W94911976 citedByCount "75" @default.
- W94911976 countsByYear W949119762012 @default.
- W94911976 countsByYear W949119762013 @default.
- W94911976 countsByYear W949119762014 @default.
- W94911976 countsByYear W949119762015 @default.
- W94911976 countsByYear W949119762016 @default.
- W94911976 countsByYear W949119762017 @default.
- W94911976 countsByYear W949119762018 @default.
- W94911976 countsByYear W949119762019 @default.
- W94911976 countsByYear W949119762020 @default.
- W94911976 countsByYear W949119762021 @default.
- W94911976 countsByYear W949119762022 @default.
- W94911976 countsByYear W949119762023 @default.
- W94911976 crossrefType "journal-article" @default.
- W94911976 hasAuthorship W94911976A5008977601 @default.
- W94911976 hasAuthorship W94911976A5014018897 @default.
- W94911976 hasAuthorship W94911976A5017134095 @default.
- W94911976 hasAuthorship W94911976A5032531829 @default.
- W94911976 hasAuthorship W94911976A5037514446 @default.
- W94911976 hasAuthorship W94911976A5038455658 @default.
- W94911976 hasAuthorship W94911976A5041295779 @default.
- W94911976 hasAuthorship W94911976A5061845242 @default.
- W94911976 hasAuthorship W94911976A5065297743 @default.
- W94911976 hasAuthorship W94911976A5065492245 @default.
- W94911976 hasAuthorship W94911976A5088917579 @default.
- W94911976 hasAuthorship W94911976A5091218113 @default.
- W94911976 hasBestOaLocation W949119762 @default.
- W94911976 hasConcept C126322002 @default.
- W94911976 hasConcept C159654299 @default.
- W94911976 hasConcept C170493617 @default.