Matches in SemOpenAlex for { <https://semopenalex.org/work/W94959975> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W94959975 endingPage "77" @default.
- W94959975 startingPage "71" @default.
- W94959975 abstract "The mechanism by which palmitoyl-CoA inhibits Ca2+ uptake in liver and heart mitochondria was examined. At a given concentration of palmitoyl-CoA, the extent of inhibition is inversely related to the concentration of the respiratory substrate succinate. Palmitoyl-CoA inhibition of uncoupler-stimulated respiration and respiration stimulated by ionophore-A23187-induced Ca2+ cycling is also relieved by high succinate concentrations. These effects of palmitoyl-CoA and succinate concentration are distinct from the increase in inner-membrane permeability, which can be produced by palmitoyl-CoA and Ca2+ [Beatrice, Palmer & Pfeiffer (1980) J. Biol. Chem. 255, 8663-8671]. The apparent K0.5 of the mitochondrial Ca2+ pump is not altered by palmitoyl-CoA. No or negligible effects of palmitoyl-CoA on the Ca2+-uptake rate are observed when ascorbate replaces succinate as an energy source. These findings, together with the known activity of palmitoyl-CoA as a competitive inhibitor of the dicarboxylate carrier [Morel, Lauquin, Lunardi, Duszynski & Vignais (1974) FEBS Lett. 39, 133-138], indicate that palmitoyl-CoA inhibits energy-linked Ca2+ transport by limiting the rate of electron transport through limitation of succinate entry into the mitochondria rather than by directly inhibiting the Ca2+ carrier." @default.
- W94959975 created "2016-06-24" @default.
- W94959975 creator A5062701468 @default.
- W94959975 creator A5086270486 @default.
- W94959975 date "1981-01-15" @default.
- W94959975 modified "2023-09-25" @default.
- W94959975 title "The mechanism of palmitoyl-CoA inhibition of Ca2+ uptake in liver and heart mitochondria" @default.
- W94959975 cites W109095382 @default.
- W94959975 cites W1485806421 @default.
- W94959975 cites W1500700435 @default.
- W94959975 cites W1516105725 @default.
- W94959975 cites W1516899109 @default.
- W94959975 cites W1576583745 @default.
- W94959975 cites W1800061482 @default.
- W94959975 cites W1851479110 @default.
- W94959975 cites W1977700008 @default.
- W94959975 cites W1981272477 @default.
- W94959975 cites W2002413733 @default.
- W94959975 cites W2006595332 @default.
- W94959975 cites W2023071841 @default.
- W94959975 cites W2024994645 @default.
- W94959975 cites W2040890373 @default.
- W94959975 cites W2047659321 @default.
- W94959975 cites W2056918831 @default.
- W94959975 cites W2060625446 @default.
- W94959975 cites W2078929761 @default.
- W94959975 cites W2079341768 @default.
- W94959975 cites W2084539931 @default.
- W94959975 cites W2094821743 @default.
- W94959975 cites W2143046500 @default.
- W94959975 cites W2402976707 @default.
- W94959975 cites W2425587840 @default.
- W94959975 cites W346743088 @default.
- W94959975 doi "https://doi.org/10.1042/bj1940071" @default.
- W94959975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1162718" @default.
- W94959975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7305993" @default.
- W94959975 hasPublicationYear "1981" @default.
- W94959975 type Work @default.
- W94959975 sameAs 94959975 @default.
- W94959975 citedByCount "15" @default.
- W94959975 crossrefType "journal-article" @default.
- W94959975 hasAuthorship W94959975A5062701468 @default.
- W94959975 hasAuthorship W94959975A5086270486 @default.
- W94959975 hasBestOaLocation W949599752 @default.
- W94959975 hasConcept C105702510 @default.
- W94959975 hasConcept C12554922 @default.
- W94959975 hasConcept C181911157 @default.
- W94959975 hasConcept C182215343 @default.
- W94959975 hasConcept C185592680 @default.
- W94959975 hasConcept C18903297 @default.
- W94959975 hasConcept C24840226 @default.
- W94959975 hasConcept C2777289219 @default.
- W94959975 hasConcept C2779014961 @default.
- W94959975 hasConcept C28859421 @default.
- W94959975 hasConcept C41625074 @default.
- W94959975 hasConcept C55493867 @default.
- W94959975 hasConcept C86803240 @default.
- W94959975 hasConceptScore W94959975C105702510 @default.
- W94959975 hasConceptScore W94959975C12554922 @default.
- W94959975 hasConceptScore W94959975C181911157 @default.
- W94959975 hasConceptScore W94959975C182215343 @default.
- W94959975 hasConceptScore W94959975C185592680 @default.
- W94959975 hasConceptScore W94959975C18903297 @default.
- W94959975 hasConceptScore W94959975C24840226 @default.
- W94959975 hasConceptScore W94959975C2777289219 @default.
- W94959975 hasConceptScore W94959975C2779014961 @default.
- W94959975 hasConceptScore W94959975C28859421 @default.
- W94959975 hasConceptScore W94959975C41625074 @default.
- W94959975 hasConceptScore W94959975C55493867 @default.
- W94959975 hasConceptScore W94959975C86803240 @default.
- W94959975 hasIssue "1" @default.
- W94959975 hasLocation W949599751 @default.
- W94959975 hasLocation W949599752 @default.
- W94959975 hasLocation W949599753 @default.
- W94959975 hasOpenAccess W94959975 @default.
- W94959975 hasPrimaryLocation W949599751 @default.
- W94959975 hasRelatedWork W1969000311 @default.
- W94959975 hasRelatedWork W1996485520 @default.
- W94959975 hasRelatedWork W2074527668 @default.
- W94959975 hasRelatedWork W2170810320 @default.
- W94959975 hasRelatedWork W2250139821 @default.
- W94959975 hasRelatedWork W2334456735 @default.
- W94959975 hasRelatedWork W2345871970 @default.
- W94959975 hasRelatedWork W2414089701 @default.
- W94959975 hasRelatedWork W2921762454 @default.
- W94959975 hasRelatedWork W3139936127 @default.
- W94959975 hasVolume "194" @default.
- W94959975 isParatext "false" @default.
- W94959975 isRetracted "false" @default.
- W94959975 magId "94959975" @default.
- W94959975 workType "article" @default.