FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W94977108> ?p ?o ?g. }

• W94977108 endingPage "1545" @default.
• W94977108 startingPage "1538" @default.
• W94977108 abstract "We sought to determine whether reperfusion and the calcium channel blocker amlodipine or the angiotensin-converting enzyme inhibitor enalapril, during healing over six weeks after myocardial infarction (MI), limit structural vascular remodeling in the noninfarct zone (NIZ).The effect of reperfusion and amlodipine or enalapril on structural vascular remodeling during healing of MI has not been determined.We randomly assigned 54 dogs to reperfused or nonreperfused MI, followed by twice-daily doses of oral placebo, amlodipine (5 mg) or enalapril (5 mg) for six weeks and three days off treatment, or to three matching sham groups. We measured in vivo hemodynamic data and left ventricular (LV) function and remodeling (by echocardiography) over the six weeks, as well as ex vivo structural vascular, ventricular and collagen remodeling in the hearts after six weeks.Compared with placebo and sham groups, both amlodipine and enalapril with or without reperfusion produced LV unloading and limited structural LV remodeling and dysfunction over six weeks in vivo, and also decreased the NIZ resistance vessel media/lumen area ratio at six weeks ex vivo. In addition, amlodipine, but not enalapril, preserved infarct scar collagen and increased the border zone collagen volume fraction and perivascular fibrosis, as well as NIZ resistance vessel media thickness. Enalapril, but not amlodipine, decreased transforming growth factor-beta in the border zone and NIZ.The results indicate that therapy with amlodipine and enalapril during healing after reperfused MI limits structural vascular remodeling in the NIZ, probably by different mechanisms." @default.
• W94977108 created "2016-06-24" @default.
• W94977108 creator A5004455536 @default.
• W94977108 creator A5016639887 @default.
• W94977108 creator A5019712916 @default.
• W94977108 creator A5081227251 @default.
• W94977108 date "2002-05-01" @default.
• W94977108 modified "2023-10-01" @default.
• W94977108 title "Vascular remodeling during healing after myocardial infarction in the dog model" @default.
• W94977108 cites W1967615630 @default.
• W94977108 cites W1968604238 @default.
• W94977108 cites W1979653272 @default.
• W94977108 cites W1991631571 @default.
• W94977108 cites W1996913240 @default.
• W94977108 cites W2003269305 @default.
• W94977108 cites W2016126378 @default.
• W94977108 cites W2016276461 @default.
• W94977108 cites W2026623200 @default.
• W94977108 cites W2034467669 @default.
• W94977108 cites W2046845297 @default.
• W94977108 cites W2048664109 @default.
• W94977108 cites W2053717115 @default.
• W94977108 cites W2055502077 @default.
• W94977108 cites W2058044929 @default.
• W94977108 cites W2060235467 @default.
• W94977108 cites W2069924575 @default.
• W94977108 cites W2070726999 @default.
• W94977108 cites W2080357572 @default.
• W94977108 cites W2103810068 @default.
• W94977108 cites W2111379992 @default.
• W94977108 cites W2123864707 @default.
• W94977108 cites W2143127285 @default.
• W94977108 cites W2166308479 @default.
• W94977108 cites W2166496450 @default.
• W94977108 cites W2273834614 @default.
• W94977108 cites W2318480619 @default.
• W94977108 doi "https://doi.org/10.1016/s0735-1097(02)01805-3" @default.
• W94977108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11985920" @default.
• W94977108 hasPublicationYear "2002" @default.
• W94977108 type Work @default.
• W94977108 sameAs 94977108 @default.
• W94977108 citedByCount "38" @default.
• W94977108 countsByYear W949771082012 @default.
• W94977108 countsByYear W949771082013 @default.
• W94977108 countsByYear W949771082014 @default.
• W94977108 countsByYear W949771082015 @default.
• W94977108 countsByYear W949771082016 @default.
• W94977108 countsByYear W949771082017 @default.
• W94977108 countsByYear W949771082018 @default.
• W94977108 countsByYear W949771082019 @default.
• W94977108 countsByYear W949771082020 @default.
• W94977108 countsByYear W949771082023 @default.
• W94977108 crossrefType "journal-article" @default.
• W94977108 hasAuthorship W94977108A5004455536 @default.
• W94977108 hasAuthorship W94977108A5016639887 @default.
• W94977108 hasAuthorship W94977108A5019712916 @default.
• W94977108 hasAuthorship W94977108A5081227251 @default.
• W94977108 hasBestOaLocation W949771081 @default.
• W94977108 hasConcept C126322002 @default.
• W94977108 hasConcept C150903083 @default.
• W94977108 hasConcept C164705383 @default.
• W94977108 hasConcept C207001950 @default.
• W94977108 hasConcept C26291073 @default.
• W94977108 hasConcept C27016395 @default.
• W94977108 hasConcept C2775940317 @default.
• W94977108 hasConcept C2779537366 @default.
• W94977108 hasConcept C2779611605 @default.
• W94977108 hasConcept C2779646130 @default.
• W94977108 hasConcept C500558357 @default.
• W94977108 hasConcept C71924100 @default.
• W94977108 hasConcept C84393581 @default.
• W94977108 hasConcept C86803240 @default.
• W94977108 hasConceptScore W94977108C126322002 @default.
• W94977108 hasConceptScore W94977108C150903083 @default.
• W94977108 hasConceptScore W94977108C164705383 @default.
• W94977108 hasConceptScore W94977108C207001950 @default.
• W94977108 hasConceptScore W94977108C26291073 @default.
• W94977108 hasConceptScore W94977108C27016395 @default.
• W94977108 hasConceptScore W94977108C2775940317 @default.
• W94977108 hasConceptScore W94977108C2779537366 @default.
• W94977108 hasConceptScore W94977108C2779611605 @default.
• W94977108 hasConceptScore W94977108C2779646130 @default.
• W94977108 hasConceptScore W94977108C500558357 @default.
• W94977108 hasConceptScore W94977108C71924100 @default.
• W94977108 hasConceptScore W94977108C84393581 @default.
• W94977108 hasConceptScore W94977108C86803240 @default.
• W94977108 hasIssue "9" @default.
• W94977108 hasLocation W949771081 @default.
• W94977108 hasLocation W949771082 @default.
• W94977108 hasOpenAccess W94977108 @default.
• W94977108 hasPrimaryLocation W949771081 @default.
• W94977108 hasRelatedWork W1863823284 @default.
• W94977108 hasRelatedWork W1983742408 @default.
• W94977108 hasRelatedWork W2018227987 @default.
• W94977108 hasRelatedWork W2034467669 @default.
• W94977108 hasRelatedWork W2113444894 @default.
• W94977108 hasRelatedWork W2326132384 @default.
• W94977108 hasRelatedWork W2370432250 @default.

• next