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- W950143338 abstract "This chapter describes that two patients with intractable Parkinson's disease showing marked improvement, when adrenal medullary fragments are grafted within the lateral ventricle with partial inclusion within the head of the caudate nucleus. Grafting adrenal medullary tissue within the lateral ventricle in close contact with the caudate nucleus, results in obvious improvements of most clinical signs of Parkinson's disease. However, many questions have remained unanswered, amongst which stands out the possible mechanisms, whereby the grafts induce such recovery in the patients. The simplest explanation could be related to the release of dopamine by the grafted tissue, which could reach the appropriate receptor sites on both sides of the brain, because improvement is bilateral. Although, the results obtained with the transplants are very encouraging, the chapter, particularly, in relation to older patients suggests that it is probably not appropriate to perform operations of this kind on very old patients with far-advanced Parkinsonism." @default.
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- W950143338 date "1988-01-01" @default.
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- W950143338 title "Chapter 73 Adrenal medullary tissue transplants in the caudate nucleus of Parkinson's patients" @default.
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- W950143338 doi "https://doi.org/10.1016/s0079-6123(08)60332-5" @default.
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