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- W95030948 abstract "Long-chain bases are potent inhibitors of the CaS , phospholipid-dependent protein kinase (PKC) both in vitro and in vivo. Low concentrations of these compounds added to Chinese hamster ovary (CHO) cells stimulated the cloning efficiency and growth of these cells; concentrations up to 4 M caused a combination of growth inhibition and cytotoxicity; and, higher concentrations led to rapid cell death. Investigation into the association between long-chain base growth effects and inhibition of PKC showed that the structural specificity necessary for these effects paralleled the potency of PKC inhibition observed in other systems. Furthermore, treatment with the long-chain base sphinganine inhibited phorbol ester-induced phosphorylation changes in CHO cells while the phosphorylation patter of a mutant cell isolated for its resistance to sphinganine toxicity was unchanged by either phorbol ester or sphinganine treatment. These results strongly suggest that inhibition of PKC by long-chain bases is related to the cytotoxicity and growth effects of these compounds." @default.
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- W95030948 date "1987-05-01" @default.
- W95030948 modified "2023-09-28" @default.
- W95030948 title "Long-chain (sphingoid) bases cause growth changes and cytotoxicity in Chinese hamster ovary cells" @default.
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