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- W9503787 abstract "In the past several decades, a number of new developments in nitrate therapy have taken place. These have primarily resulted from alteration of the pharmacokinetic properties of this class of vasodilators, rather than attempts to increase their potency or cardiovascular selectivity. This general direction appears rational in view of the fact that the major short-coming of the early nitrates viz, amyl nitrite and nitroglycerin (NTG), is their short duration of action. The discovery of “long-acting” nitrates such as isosorbide dinitrate (ISDN), erythrityl tetranitrate (ETN) and pentaerythrityl tetranitrate (PETN) heralded this strategy. The development of retard dosage forms, either through oral or transdermal routes [6], is another example of this approach. Recently, substantial interests have been generated in using the active metabolites of known organic nitrates to prolong the duration of nitrate action. A prime example of this approach involves the use of the major metabolite of ISDN, isosorbide-5-mononitrate (IS-5-MN). The pharmacokinetic properties of the latter compound are considerably more straight forward than those of ISDN: IS-5-MN has a longer biological half-life, does not undergo first-pass metabolism, and is completely absorbed after oral administration [1]. In addition, IS-5-MN pharmacokinetics are little affected in patients with either liver or renal disease [2, 18]." @default.
- W9503787 created "2016-06-24" @default.
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- W9503787 date "1987-01-01" @default.
- W9503787 modified "2023-09-23" @default.
- W9503787 title "Pharmacokinetics of Organic Nitrates and Their Metabolites: Are They Relevant in Therapy?" @default.
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- W9503787 doi "https://doi.org/10.1007/978-3-642-72689-7_7" @default.
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