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- W95054360 abstract "Natural and induced factors inhibiting foot and mouth diseasevirus were investigated in bovine secretions, especially in those fromthe upper respiratory and oro pharyngeal areas. Techniques weredevised to collect lachrymal, nasal, buccal and pharyngeal fluids fromnormal, convalescent and passively or actively immunised steers.The pH and total protein content of secretions were establishedin normal cattle. Immunoglobulin types IgA and IgGl predominated.Interferon was not detected. Normal tears exhibited no antiviralactivity but nasal secretion, oral saliva and p~al fluid wereinhibitory due to their alkaline pH and, in the case of salivaryfluids, to the presence of an additional anti viral factor which waspartially characterised. Virus lost infectivity in vitro due tonatural, non specific factors at rates which varied with the strain ofvirus to a maximum of 1.25 log units per hour.Clinical disease, viral excretion, interferon and antibody werestudied following infection with virus of types 0, A and C. Interferonwas detected for up to 4 days at the period of maximum viral excretion.Secretory neutralising antibody developed , - 5 days after exposure,reached a peak within 21 - 28 days and was associated principally withIgA and IgGl. Serum levels were consistently greater than those insecretions. Passive immunisation studies showed that some secretoryantibody was derived from serum.years after infection.Antibody persisted for at least ~Secretory antibody levels increased with successive subcutaneousdoses of inactivated vaccine. A single dose elicited good humoral butpoor secretory responses. Levels in serum and secretions rose aftera second dose and approached convalescent levels after a third.Secretory antibody was principally IgGl but after a third vaccinationIgA was also detected.The relation between secretory antibody and the outcome of exposureto infection was studied. In steers vaccinated once or twice andexposed 14 days after the last vaccination, no lesions were observedand little virus was recovered from their secretions excepting pharyngealfluid. After three vaccinations much less pharyngeal virus wasrecovered following exposure. Convalescent animals reexposed 5 and a half yearsafter primary infection were immune and did not become carriers,pharyngeal samples remaining negative. These observations correlatedwell with the presence of neutralising IgA in the secretions." @default.
- W95054360 created "2016-06-24" @default.
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- W95054360 date "1974-01-01" @default.
- W95054360 modified "2023-09-27" @default.
- W95054360 title "The inhibitory activity of secretions in cattle against foot and mouth disease virus." @default.
- W95054360 doi "https://doi.org/10.17037/pubs.00878722" @default.
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