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- W95073513 abstract "In the past century cholesterol played a predominant role in research on the etiology of CHD. On the basis of largely experimental work in rabbits and on cross-cultural comparisons of serum cholesterol levels in humans, the hypothesis was formed that arteriosclerosis and its complications were associated with hypercholesterolemia (1). Cholesterol is transported in the blood in lipoprotein fractions. In the 1950s it was shown in clinical studies that the Low Density Lipoprotein (LDL) fraction in cardiac patients was higher, and the High Density Lipoprotein (HDL) fraction lower, when compared with controls (2). Advances in the genetics and cellular biology of cholesterol increased understanding about the role of mechanisms by which genes, hormones, and diet regulate serum cholesterol levels (3). Critical components of this system are lipoprotein receptors in the liver and extra-hepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins." @default.
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- W95073513 date "2002-01-01" @default.
- W95073513 modified "2023-09-23" @default.
- W95073513 title "Serum Cholesterol and Coronary Heart Disease in the Seven Countries Study" @default.
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