Matches in SemOpenAlex for { <https://semopenalex.org/work/W95080690> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W95080690 endingPage "235" @default.
- W95080690 startingPage "223" @default.
- W95080690 abstract "Candida albicans is a member of the normal oral and gut microbiota and is also an opportunistic pathogen causing oral and genital infections in humans. Two of the Hsp70 proteins of this organism, Ssa 1 and Ssa 2, show unusual biological actions, presumably moonlighting actions, which contribute to the interaction of this yeast with its host. Both Ssa 1/2 are found on the outer surface of the fungus and this location provides novel functions for these proteins. It also appears to be an Achilles heel of this fungus. The Hsp70 proteins are highly immunogenic and so the surface location of Ssa 1/2 makes a good immunological target for innate and adaptive immune responses to this organism and also suggests these proteins could be vaccine candidates. Surprisingly, Ssa 1/2 binds to the antifungal peptide Histatin (Hst) 5 and enables this toxic molecule to be taken up by the yeast causing cell death. In spite of these findings, C. albicans lacking Ssa 1, but not Ssa 2, were significantly less virulent in infected mice and this was related to the loss of invasiveness of this fungus. Thus these Hsp70 proteins play unexpected roles in the lifestyle of C. albicans." @default.
- W95080690 created "2016-06-24" @default.
- W95080690 creator A5036961404 @default.
- W95080690 creator A5042515687 @default.
- W95080690 date "2013-01-01" @default.
- W95080690 modified "2023-09-23" @default.
- W95080690 title "Candida albicans Ssa: An Hsp70 Homologue and Virulence Factor" @default.
- W95080690 cites W1554180547 @default.
- W95080690 cites W1760120130 @default.
- W95080690 cites W1881586215 @default.
- W95080690 cites W1967864456 @default.
- W95080690 cites W1982049298 @default.
- W95080690 cites W1992376704 @default.
- W95080690 cites W1993127371 @default.
- W95080690 cites W1993146308 @default.
- W95080690 cites W1994434480 @default.
- W95080690 cites W1995351663 @default.
- W95080690 cites W1995412010 @default.
- W95080690 cites W2002696633 @default.
- W95080690 cites W2010999630 @default.
- W95080690 cites W2012339382 @default.
- W95080690 cites W2031431271 @default.
- W95080690 cites W2034700901 @default.
- W95080690 cites W2043295775 @default.
- W95080690 cites W2045507047 @default.
- W95080690 cites W2048141156 @default.
- W95080690 cites W2048908946 @default.
- W95080690 cites W2053300791 @default.
- W95080690 cites W2054063955 @default.
- W95080690 cites W2054607729 @default.
- W95080690 cites W2055917268 @default.
- W95080690 cites W2063656851 @default.
- W95080690 cites W2070837164 @default.
- W95080690 cites W2077155024 @default.
- W95080690 cites W2087273774 @default.
- W95080690 cites W2090227081 @default.
- W95080690 cites W2097840941 @default.
- W95080690 cites W2107364505 @default.
- W95080690 cites W2113602073 @default.
- W95080690 cites W2116142727 @default.
- W95080690 cites W2122436557 @default.
- W95080690 cites W2129004089 @default.
- W95080690 cites W2129629034 @default.
- W95080690 cites W2132320427 @default.
- W95080690 cites W2144737284 @default.
- W95080690 cites W2151298994 @default.
- W95080690 doi "https://doi.org/10.1007/978-94-007-6787-4_14" @default.
- W95080690 hasPublicationYear "2013" @default.
- W95080690 type Work @default.
- W95080690 sameAs 95080690 @default.
- W95080690 citedByCount "2" @default.
- W95080690 countsByYear W950806902016 @default.
- W95080690 countsByYear W950806902022 @default.
- W95080690 crossrefType "book-chapter" @default.
- W95080690 hasAuthorship W95080690A5036961404 @default.
- W95080690 hasAuthorship W95080690A5042515687 @default.
- W95080690 hasConcept C104317684 @default.
- W95080690 hasConcept C2780917455 @default.
- W95080690 hasConcept C2781090273 @default.
- W95080690 hasConcept C54355233 @default.
- W95080690 hasConcept C60987743 @default.
- W95080690 hasConcept C86803240 @default.
- W95080690 hasConcept C89423630 @default.
- W95080690 hasConceptScore W95080690C104317684 @default.
- W95080690 hasConceptScore W95080690C2780917455 @default.
- W95080690 hasConceptScore W95080690C2781090273 @default.
- W95080690 hasConceptScore W95080690C54355233 @default.
- W95080690 hasConceptScore W95080690C60987743 @default.
- W95080690 hasConceptScore W95080690C86803240 @default.
- W95080690 hasConceptScore W95080690C89423630 @default.
- W95080690 hasLocation W950806901 @default.
- W95080690 hasOpenAccess W95080690 @default.
- W95080690 hasPrimaryLocation W950806901 @default.
- W95080690 hasRelatedWork W1783221250 @default.
- W95080690 hasRelatedWork W1990652136 @default.
- W95080690 hasRelatedWork W2037993165 @default.
- W95080690 hasRelatedWork W2094907101 @default.
- W95080690 hasRelatedWork W2114686516 @default.
- W95080690 hasRelatedWork W2147946690 @default.
- W95080690 hasRelatedWork W2156960740 @default.
- W95080690 hasRelatedWork W2171788590 @default.
- W95080690 hasRelatedWork W4297541662 @default.
- W95080690 hasRelatedWork W2736951987 @default.
- W95080690 isParatext "false" @default.
- W95080690 isRetracted "false" @default.
- W95080690 magId "95080690" @default.
- W95080690 workType "book-chapter" @default.