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- W951143954 abstract "Chickenpox (varicella) is caused by primary infection with varicella zoster virus (VZV), which can establish long-term latency in the host ganglion. Once reactivated, the virus can cause shingles (zoster) in the host. VZV has a typical herpesvirus virion structure consisting of an inner DNA core, a capsid, a tegument, and an outer envelope. The tegument is an amorphous layer enclosed between the nucleocapsid and the envelope, which contains a variety of proteins. However, the types and functions of VZV tegument proteins have not yet been completely determined. In this review, we describe the current knowledge on the multiple roles played by VZV tegument proteins during viral infection. Moreover, we discuss the VZV tegument protein-protein interactions and their impact on viral tissue tropism in SCID-hu mice. This will help us develop a better understanding of how the tegument proteins aid viral DNA replication, evasion of host immune response, and pathogenesis." @default.
- W951143954 created "2016-06-24" @default.
- W951143954 creator A5024228040 @default.
- W951143954 creator A5034044681 @default.
- W951143954 creator A5086284188 @default.
- W951143954 creator A5088393966 @default.
- W951143954 date "2015-07-24" @default.
- W951143954 modified "2023-10-05" @default.
- W951143954 title "Insights into the function of tegument proteins from the varicella zoster virus" @default.
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