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- W951150129 abstract "There is no doubt that viral vectors hold the promise of transforming the field of psychiatry. However, safe and efficacious gene therapy for psychiatric disorders is several years from becoming reality. Regardless, viral vectors are already providing useful information to basic science in the investigation into the molecular determinants of behavior. Viral vectors expressing the transcription factor, cAMP-response-element binding protein (CREB) or a dominant-negative mutant form of CREB (mCREB) affect behavior in rodent models ranging from depression to anxiety to drug dependence. This chapter compares and contrasts four viral vector systems (herpes simplex 1 virus, adeno-associated virus, sindbis virus, and lentivirus) best suited for gene transfer into brain and describes basic strategies where viral-mediated gene transfer has proven useful. The final section outlines novel uses and improvements to vector technology and describes current obstacles preventing viral vectors from becoming clinically viable." @default.
- W951150129 created "2016-06-24" @default.
- W951150129 creator A5049993782 @default.
- W951150129 creator A5083697705 @default.
- W951150129 date "2006-01-01" @default.
- W951150129 modified "2023-09-24" @default.
- W951150129 title "Psychiatric Applications of Viral Vectors" @default.
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- W951150129 doi "https://doi.org/10.1016/b978-012397632-1/50015-0" @default.
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