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- W95120466 abstract "Group A streptococcus GAS‚ causes many diseases such as impetigo, necrotizing fasciitis, acute rheumatic fever, and rheumatic heart disease. More than 100 M-serotypes or emm-sequence types have been identified. The bacterial surface M protein, an important virulence factor of GAS, consists of highly variable region N-region‚ and highly conserved region C-region‚. Although antibodies specific for conserved C-region may offer coverage against different GAS serotypes, these antibodies are weekly immunogenic and cross-reactive with human tissues heart, brain, kidney or joint cartilage‚. On the other hands, N-region epitopes can elicit greater immune response than C-region epitopes, however N-region antibodies are strain specific. Multivalent vaccine strategy, such as multiple antigen peptide, would contribute to prevention against various GAS infections and provide better protective immunity. We have been researching on synthesis of multivalent GAS vaccine, which has various peptide epitopes in single molecular 1‚. We present the synthesis of multiepitopic peptide vaccine using chemoselective ligation technique and their immunological characters." @default.
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- W95120466 date "2007-01-01" @default.
- W95120466 modified "2023-10-18" @default.
- W95120466 title "Development of a Multivalent Heteroepitopic Group A Streptococcus Vaccine" @default.
- W95120466 hasPublicationYear "2007" @default.
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