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- W95121844 endingPage "88" @default.
- W95121844 startingPage "57" @default.
- W95121844 abstract "Autophagy has recently gained considerable attention as an essential contributor to human health and disease. In the GI tract, autophagy has a major role in the maintenance of homeostasis and defects in the autophagic pathway are strongly associated with a major form of idiopathic inflammatory bowel disease—Crohn’s disease (CD). Recent genetic studies have implicated polymorphisms in two autophagy-related genes, Atg16L1 and IRGM , as risk factors for the development of Crohn’s disease and other CD-associated factors have been shown to interact with the autophagic pathway. In this chapter, we discuss the implications of impaired autophagy in different aspects of Crohn’s disease pathogenesis and describe the recent advances in autophagy research regarding its role in health and disease in the GI tract." @default.
- W95121844 created "2016-06-24" @default.
- W95121844 creator A5053512025 @default.
- W95121844 creator A5076702490 @default.
- W95121844 date "2013-01-01" @default.
- W95121844 modified "2023-10-05" @default.
- W95121844 title "Autophagy in the Gastrointestinal Tract" @default.
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