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- W951241330 abstract "Nanoparticles have been proven to be an effective vaccine delivery system that can boost immune responses to subunit vaccines. Herein, we developed and characterized a cationic polymeric polyethylene glycol2000-poly ϵ-caprolactone2000-polyethylenimine2000 (mPEG2000-PCL2000-g-PEI2000) micelle as a potent vaccine delivery system to boost the immune response in vivo. The micelles that we developed exhibited great antigen-loading capability and minimal cytotoxicity in vitro. Meanwhile, micelles facilitated OVA antigen uptake by dendritic cells both in vitro and in vivo. More importantly, a micelle-formulated OVA vaccine could significantly promote anti-OVA antibody production by 190-fold and potently enhance T cell proliferation and the secretion of IL-5 and IFN-γ. We attributed these effects to its ability to promote antigen uptake, antigen deposition, and germinal center formation. In conclusion, the mPEG2000-PCL2000-PEI2000 micelle that we developed has potential as potent vaccine delivery system to induce Th2 immune response." @default.
- W951241330 created "2016-06-24" @default.
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- W951241330 date "2015-11-01" @default.
- W951241330 modified "2023-09-25" @default.
- W951241330 title "Cationic micelle based vaccine induced potent humoral immune response through enhancing antigen uptake and formation of germinal center" @default.
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- W951241330 doi "https://doi.org/10.1016/j.colsurfb.2015.07.079" @default.
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