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- W951275402 abstract "Objective Previous work from this lab has shown that exposure to nicotine causes an immediate (3 hour) increase in expression of TGF-β1. We hypothesized that chronic exposure of VSMC to free-base nicotine in vitro would cause sustained up regulation of TGF-β1. Methods VSMC grown in vitro were exposed to 10−6 M FBN for 24 (day 1), 72 (day 3), and 144 hours (day 6). Control cells were exposed to growth media without FBN. Expression TGF-β1 was determined by immunocytochemistry and an intensity stain index was measured quantitatively using digital image analysis. Results After 24 hour exposure to FBN, TGF-β1 was down regulated when compared to control (132± 7.35 vs. 152± 5.31, p=.03). After 72, and 144 hours exposure, the decrease in expression of TGF-β1, when compared to the 24 hours, continues and is significant, (114.4 ± 6.8 vs.132.8 ± 7.35, p=.05) and (95.2±3.9 vs. 132.8 ± 7.35, p=.004) Conclusion Although exposure of VSMC's to nicotine causes an acute increase of TGf-β1, the long-term impact is down regulation of TGF-β1 expression. These observations imply that TGF-β1 is only involved in the acute phase of the inflammatory response to nicotine." @default.
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- W951275402 date "2006-03-01" @default.
- W951275402 modified "2023-09-25" @default.
- W951275402 title "TGF‐β1 Expression in Human Aortic Smooth Muscle Cells (VSMC) is Down‐regulated when Exposed to Nicotine In Vitro for Six Days" @default.
- W951275402 doi "https://doi.org/10.1096/fasebj.20.5.lb116" @default.
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