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• W951317561 endingPage "e0131403" @default.
• W951317561 startingPage "e0131403" @default.
• W951317561 abstract "Numerous agents targeting PD-L1/PD-1 check-point are in clinical development. However, the correlation between PD-L1 expression and prognosis of solid tumor is still in controversial. Here, we elicit a systematic review and meta-analysis to investigate the potential value of PD-L1 in the prognostic prediction in human solid tumors.Electronic databases were searched for studies evaluating the expression of PD-L1 and overall survival (OS) of patients with solid tumors. Odds ratios (ORs) from individual studies were calculated and pooled by using a random-effect model, and heterogeneity and publication bias analyses were also performed.A total of 3107 patients with solid tumor from 28 published studies were included in the meta-analysis. The median percentage of solid tumors with PD-L1 overexpression was 52.5%. PD-L1 overexpression was associated with worse OS at both 3 years (OR = 2.43, 95% confidence interval (CI) = 1.60 to 3.70, P < 0.0001) and 5 years (OR = 2.23, 95% CI = 1.40 to 3.55, P = 0.0008) of solid tumors. Among the tumor types, PD-L1 was associated with worse 3 year-OS of esophageal cancer, gastric cancer, hepatocellular carcinoma, and urothelial cancer, and 5 year-OS of esophageal cancer, gastric cancer and colorectal cancer.These results suggest that expression of PD-L1 is associated with worse survival in solid tumors. However, the correlations between PD-L1 and prognosis are variant among different tumor types. More studies are needed to investigate the clinical value of PD-L1 expression in prognostic prediction and treatment option." @default.
• W951317561 created "2016-06-24" @default.
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• W951317561 date "2015-06-26" @default.
• W951317561 modified "2023-09-29" @default.
• W951317561 title "PD-L1 and Survival in Solid Tumors: A Meta-Analysis" @default.
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• W951317561 doi "https://doi.org/10.1371/journal.pone.0131403" @default.
• W951317561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4483169" @default.
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• W951317561 hasPublicationYear "2015" @default.
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