FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W952001987> ?p ?o ?g. }

• W952001987 endingPage "6920" @default.
• W952001987 startingPage "6910" @default.
• W952001987 abstract "The peptide binding site of MHC class II molecules is open at both ends and, therefore, does not restrict the length of the bound ligand. Here we show that a partially folded protein antigen (*HEL) spontaneously formed SDS-unstable complexes with the purified MHC class II molecule I-Ak (Ak). These complexes were also detected on the surface of antigen-presenting cells (APCs) where they stimulated T cells. However, they rapidly disappeared after endocytosis. Intracellular processing of *HEL gave rise to SDS-stable, long-lived Ak complexes containing *HEL peptides and, unexpectedly, full-length *HEL. Both SDS-stable products were formed in low pH compartments and then transported to the plasma membrane. In contrast to *HEL peptides, the stable association of *HEL occurred in an alternative pathway that required mature class II molecules and did not involve HLA-DM or proteases. SDS-stable *HEL-Ak complexes were formed by a reaction of endosomal Ak with endocytosed *HEL, but not by direct conversion of SDS-unstable complexes derived from the plasma membrane. Our work establishes a fundamental difference between the two MHC class II loading pathways and for the first time demonstrates a full-length protein as a product of antigen processing." @default.
• W952001987 created "2016-06-24" @default.
• W952001987 creator A5055371968 @default.
• W952001987 creator A5079811330 @default.
• W952001987 date "1996-12-01" @default.
• W952001987 modified "2023-10-14" @default.
• W952001987 title "Distinct antigen MHC class II complexes generated by separate processing pathways." @default.
• W952001987 cites W1014366764 @default.
• W952001987 cites W113162970 @default.
• W952001987 cites W1533588026 @default.
• W952001987 cites W1570511160 @default.
• W952001987 cites W1576281768 @default.
• W952001987 cites W1579578038 @default.
• W952001987 cites W1602817079 @default.
• W952001987 cites W1643239212 @default.
• W952001987 cites W1646593409 @default.
• W952001987 cites W1734730736 @default.
• W952001987 cites W1782927503 @default.
• W952001987 cites W1884828489 @default.
• W952001987 cites W1967891379 @default.
• W952001987 cites W1969063687 @default.
• W952001987 cites W1975085160 @default.
• W952001987 cites W1975085335 @default.
• W952001987 cites W1977631515 @default.
• W952001987 cites W1979038840 @default.
• W952001987 cites W1981143248 @default.
• W952001987 cites W1983122260 @default.
• W952001987 cites W1984288819 @default.
• W952001987 cites W1998606811 @default.
• W952001987 cites W2001737867 @default.
• W952001987 cites W2004379008 @default.
• W952001987 cites W2004443127 @default.
• W952001987 cites W2009846725 @default.
• W952001987 cites W2011455528 @default.
• W952001987 cites W2015373718 @default.
• W952001987 cites W2017936764 @default.
• W952001987 cites W2026987532 @default.
• W952001987 cites W2028473507 @default.
• W952001987 cites W2033893498 @default.
• W952001987 cites W2039823819 @default.
• W952001987 cites W2041915582 @default.
• W952001987 cites W2048172864 @default.
• W952001987 cites W2051055933 @default.
• W952001987 cites W2051793369 @default.
• W952001987 cites W2072034032 @default.
• W952001987 cites W2074222872 @default.
• W952001987 cites W2077924138 @default.
• W952001987 cites W2079090605 @default.
• W952001987 cites W2080956086 @default.
• W952001987 cites W2083227510 @default.
• W952001987 cites W2084389750 @default.
• W952001987 cites W2087106927 @default.
• W952001987 cites W2092001426 @default.
• W952001987 cites W2092325349 @default.
• W952001987 cites W2092526035 @default.
• W952001987 cites W2095352046 @default.
• W952001987 cites W2107857115 @default.
• W952001987 cites W2116986357 @default.
• W952001987 cites W2130642272 @default.
• W952001987 cites W2134364025 @default.
• W952001987 cites W2140050918 @default.
• W952001987 cites W2152280976 @default.
• W952001987 cites W2171086365 @default.
• W952001987 cites W2174160083 @default.
• W952001987 cites W264140057 @default.
• W952001987 cites W2911320348 @default.
• W952001987 doi "https://doi.org/10.1002/j.1460-2075.1996.tb01083.x" @default.
• W952001987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/452517" @default.
• W952001987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9003767" @default.
• W952001987 hasPublicationYear "1996" @default.
• W952001987 type Work @default.
• W952001987 sameAs 952001987 @default.
• W952001987 citedByCount "110" @default.
• W952001987 countsByYear W9520019872012 @default.
• W952001987 countsByYear W9520019872013 @default.
• W952001987 countsByYear W9520019872015 @default.
• W952001987 countsByYear W9520019872016 @default.
• W952001987 countsByYear W9520019872017 @default.
• W952001987 countsByYear W9520019872018 @default.
• W952001987 countsByYear W9520019872020 @default.
• W952001987 countsByYear W9520019872022 @default.
• W952001987 crossrefType "journal-article" @default.
• W952001987 hasAuthorship W952001987A5055371968 @default.
• W952001987 hasAuthorship W952001987A5079811330 @default.
• W952001987 hasBestOaLocation W9520019872 @default.
• W952001987 hasConcept C102747710 @default.
• W952001987 hasConcept C108249834 @default.
• W952001987 hasConcept C147483822 @default.
• W952001987 hasConcept C170493617 @default.
• W952001987 hasConcept C170627219 @default.
• W952001987 hasConcept C181199279 @default.
• W952001987 hasConcept C182220744 @default.
• W952001987 hasConcept C197695756 @default.
• W952001987 hasConcept C203014093 @default.
• W952001987 hasConcept C207936829 @default.
• W952001987 hasConcept C22845430 @default.
• W952001987 hasConcept C2776090121 @default.
• W952001987 hasConcept C2778814158 @default.

• next