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- W952017013 abstract "目的 评价术后镇痛中帕瑞昔布钠对吗啡用量的节俭作用和安全性.方法 前瞻性、多中心、随机、双盲、安慰剂对照、平行分组研究,18～64岁、ASAⅠ或Ⅱ级、择期硬膜外腔阻滞下骨科和妇科手术病人,手术结束时,随机静脉注射帕瑞昔布钠40 mg或生理盐水2 ml,12 h后再静脉注射帕瑞昔布钠40 mg或生理盐水2 ml,同时采用吗啡进行病人自控静脉镇痛.观察术后吗啡的用量、病人自控镇痛(PCA)总次数和PCA有效次数、术后2、4、6、12和24 h的疼痛强度(VAS评分)、镇痛的补救措施、不良反应和病人对镇痛的满意度以及给药前后的生化指标和生命体征.结果 共完成223例,其中采用帕瑞昔布钠114例,安慰剂109例.与安慰剂组相比,帕瑞昔布钠组术后12 h和24 h吗啡用量减少(分别平均减少40.9%和46.1%),术后12 h和24 h PCA总次数和PCA有效次数降低(P＜0.05或0.01),术后4、6、12和24 h VAS评分降低,术后24 h满意度明显提高(P＜0.01),而有关不良反应和化验结果异常发生率的差异无统计学意义(P＞0.05).结论 在我国妇科和骨科手术后静脉给予帕瑞昔布钠40 mg bid可安全地减少术后吗啡用量,提高病人术后镇痛质量。" @default.
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