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- W952284089 abstract "目的探讨p16^INK4A蛋白在子宫颈鳞癌（SCC）和子宫颈上皮内肿瘤（CIN）中的表达及其与HPV16/18感染的关系。方法用原位杂交法检测HPV16/18在25例子宫颈癌、45例CIN及10例慢性子宫颈炎中的表达,同时用免疫组化EliVision法检测p16INK4A蛋白的表达。结果（1）与慢性子宫颈炎相比,CINⅡ级、CINⅢ级、浸润癌HPV16/18杂交信号阳性率显著增高（P〈0.01）;（2）子宫颈鳞癌组织、CINⅠ级、CINⅡ级、Ⅲ级及慢性子宫颈炎标本中p16^INK4A蛋白阳性率分别为100.0%、20.0%、46.7%、100.0%和10.0%;（3）在子宫颈鳞癌及CIN HPV16/18感染的标本中p16^INK4A蛋白表达均是阳性。结论子宫颈鳞癌的形成与HPV感染、p16^INK4A蛋白过表达是呈正相关关系,p16^INK4A蛋白可能作为子宫颈鳞癌及CIN的标志物,对子宫颈癌筛查和预防有重要意义。" @default.
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- W952284089 date "2008-01-01" @default.
- W952284089 modified "2023-10-18" @default.
- W952284089 title "子宫颈病变中p16^INK4A蛋白表达及其与HPV16/18感染的关系" @default.
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