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- W952362023 abstract "The FES/FPS-encodes Fes/Fps protein-tyrosine kinase, which is primarily expressed in hematopoietic myeloid cells, possesses specificity for tyrosine residues and phosphorylates itself and exogenous substrates in an in vitro assay. Fes/Fps has been identified on the basis of its sequence similarity to the viral oncogene products from various feline and chicken sarcoma viruses, which apparently have acquired portions of the cellular FES/FPS genes of these species through recombination. Fes/Fps is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3. The FES/FPS gene consists of 19 exons with the translational start codon in exon 2 and stop codon in exon 19. The amino acid sequences of Fes/Fps of human, cat, and chicken have been deduced from comparative analysis of the genomic DNAs and the corresponding viral DNAs of feline and chicken sarcoma viruses. The amino acid sequences of the FES/FPS kinases of human and mouse have been deduced also from human and mouse FES/FPS cDNA sequences (human placenta and KG1 cells; murine monocytes)." @default.
- W952362023 created "2016-06-24" @default.
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- W952362023 date "1995-01-01" @default.
- W952362023 modified "2023-09-26" @default.
- W952362023 title "Fes/Fps" @default.
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- W952362023 doi "https://doi.org/10.1016/b978-012324719-3/50152-7" @default.
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