Matches in SemOpenAlex for { <https://semopenalex.org/work/W95255689> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W95255689 endingPage "1544" @default.
- W95255689 startingPage "1539" @default.
- W95255689 abstract "INTRODUCTION Epstein-Barr virus is a ubiquitous human herpes virus in the Hungarian population. The virus is associated with an increasing number of lymphoid malignancies, such as Hodgkin and non-Hodgkin lymphomas. The ability of the virus to establish life-long persistent infection and induce growth transformation is related to the viral proteins that are variously expressed in both normal and malignant cells. Although the presence of ZEBRA protein induces lytic cycle, some lymphoma cases show this protein expression. AIM In our present study we investigated the frequency of expression of ZEBRA protein in Hungarian patients with Hodgkin lymphoma associated with Epstein-Barr virus infection. The authors wanted to clarify whether this expression is specific to latency type II or occurs in some non-Hodgkin lymphoma cases with latency type III as well. Does the expression of ZEBRA protein have any effect on therapeutic response and survival rate of the patients? METHOD 109 HL and 59 NHL were studied for the presence of the virus in the tumor and for expression of the latency proteins and ZEBRA by immunohistochemistry. RESULTS 25 samples were evaluated successfully for ZEBRA of the 47 LMP1 positive HL samples. We detected the weak expression of ZEBRA protein in 13 of the 25 LMP1 positive Hodgkin lymphoma cases and in 6 of the 18 LMP1 positive non-Hodgkin lymphoma samples. The authors could not find correlation between the expression of ZEBRA protein and the type of latency. During the followed 120 months the total survival of patients with ZEBRA positivity proved to be significantly shorter as compared to that of ZEBRA negative cases. The authors could not find significant difference in the uneventful survival of these two groups. CONCLUSION In the examined group of patients the ZEBRA positivity associated with a poor prognosis of the disease. Besides this relatively small number of cases, additional extensive studies are needed to conclude our observation. Elucidation of the switching mechanisms by which Epstein-Barr virus induces lytic cycle may provide an efficacious therapeutic approach to the EBV-related malignancies." @default.
- W95255689 created "2016-06-24" @default.
- W95255689 creator A5012342629 @default.
- W95255689 creator A5022880045 @default.
- W95255689 creator A5027342247 @default.
- W95255689 creator A5061458125 @default.
- W95255689 creator A5072054093 @default.
- W95255689 creator A5076380897 @default.
- W95255689 creator A5087933217 @default.
- W95255689 date "2006-08-20" @default.
- W95255689 modified "2023-10-16" @default.
- W95255689 title "[Expression of ZEBRA protein of Epstein-Barr virus in Hungarian patients with Hodgkin lymphoma: latent or lytic cycle?]." @default.
- W95255689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17037676" @default.
- W95255689 hasPublicationYear "2006" @default.
- W95255689 type Work @default.
- W95255689 sameAs 95255689 @default.
- W95255689 citedByCount "0" @default.
- W95255689 crossrefType "journal-article" @default.
- W95255689 hasAuthorship W95255689A5012342629 @default.
- W95255689 hasAuthorship W95255689A5022880045 @default.
- W95255689 hasAuthorship W95255689A5027342247 @default.
- W95255689 hasAuthorship W95255689A5061458125 @default.
- W95255689 hasAuthorship W95255689A5072054093 @default.
- W95255689 hasAuthorship W95255689A5076380897 @default.
- W95255689 hasAuthorship W95255689A5087933217 @default.
- W95255689 hasConcept C159047783 @default.
- W95255689 hasConcept C182615771 @default.
- W95255689 hasConcept C203014093 @default.
- W95255689 hasConcept C2522874641 @default.
- W95255689 hasConcept C2779020855 @default.
- W95255689 hasConcept C2779338263 @default.
- W95255689 hasConcept C2781375147 @default.
- W95255689 hasConcept C2908647359 @default.
- W95255689 hasConcept C502942594 @default.
- W95255689 hasConcept C71924100 @default.
- W95255689 hasConcept C86803240 @default.
- W95255689 hasConcept C99454951 @default.
- W95255689 hasConceptScore W95255689C159047783 @default.
- W95255689 hasConceptScore W95255689C182615771 @default.
- W95255689 hasConceptScore W95255689C203014093 @default.
- W95255689 hasConceptScore W95255689C2522874641 @default.
- W95255689 hasConceptScore W95255689C2779020855 @default.
- W95255689 hasConceptScore W95255689C2779338263 @default.
- W95255689 hasConceptScore W95255689C2781375147 @default.
- W95255689 hasConceptScore W95255689C2908647359 @default.
- W95255689 hasConceptScore W95255689C502942594 @default.
- W95255689 hasConceptScore W95255689C71924100 @default.
- W95255689 hasConceptScore W95255689C86803240 @default.
- W95255689 hasConceptScore W95255689C99454951 @default.
- W95255689 hasIssue "33" @default.
- W95255689 hasLocation W952556891 @default.
- W95255689 hasLocation W952556892 @default.
- W95255689 hasOpenAccess W95255689 @default.
- W95255689 hasPrimaryLocation W952556891 @default.
- W95255689 hasRelatedWork W142012039 @default.
- W95255689 hasRelatedWork W1592705170 @default.
- W95255689 hasRelatedWork W1983563681 @default.
- W95255689 hasRelatedWork W1991226842 @default.
- W95255689 hasRelatedWork W2011270702 @default.
- W95255689 hasRelatedWork W2040291358 @default.
- W95255689 hasRelatedWork W2111930835 @default.
- W95255689 hasRelatedWork W2137424665 @default.
- W95255689 hasRelatedWork W2165426569 @default.
- W95255689 hasRelatedWork W2171684374 @default.
- W95255689 hasRelatedWork W2355420161 @default.
- W95255689 hasRelatedWork W23607590 @default.
- W95255689 hasRelatedWork W2379093647 @default.
- W95255689 hasRelatedWork W2398908026 @default.
- W95255689 hasRelatedWork W2411122656 @default.
- W95255689 hasRelatedWork W2414030127 @default.
- W95255689 hasRelatedWork W2414636099 @default.
- W95255689 hasRelatedWork W2418947186 @default.
- W95255689 hasRelatedWork W2781889751 @default.
- W95255689 hasRelatedWork W2550428981 @default.
- W95255689 hasVolume "147" @default.
- W95255689 isParatext "false" @default.
- W95255689 isRetracted "false" @default.
- W95255689 magId "95255689" @default.
- W95255689 workType "article" @default.