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- W952634149 abstract "Every year lung cancer claims more lives than any other cancer type. Poor outcomes in this disease are linked to the development of resistance to existing treatments, including radiotherapy. Radioresistance in lung cancer may be driven by a population of cancer cells with properties in common with normal stem cells, including limitless self-renewing potential. These “cancer stem cells” are capable of reconstituting tumors following treatment and of seeding metastatic sites. In this chapter, we review the evidence implicating cancer stem cells in the radioresistance of cancers of the lung and other tissues. Strategies for interfering with mechanisms of radioresistance within cancer stem cells are discussed. Therapeutic modifications that augment the effects of radiotherapy on CSCs are likely to improve outcomes for lung cancer patients." @default.
- W952634149 created "2016-06-24" @default.
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- W952634149 date "2013-02-27" @default.
- W952634149 modified "2023-09-23" @default.
- W952634149 title "Overcoming Radioresistance of Lung Cancer Stem Cells" @default.
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- W952634149 doi "https://doi.org/10.1007/978-94-017-8032-2_11" @default.
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