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- W953062034 abstract "A kutatas legfőbb eredmenyei az alabbiak: 1. Igazoltuk, hogy a PACAP neuroprotektiv es altalanos citoprotektiv hatasainak hattereben az apoptosis, gyulladas es oxidativ stressz okozta karosodas elleni hatasok allnak. Szamos ebben resztvevő jelatviteli utvonalat, gyulladasos es oxidativ stressz markert irtunk le. 2. Igazoltuk a PACAP sejtvedő hatasat kulonboző karosodas modellekben retinaban, belső fulben, koponyatraumaban, ischemias szervi karosodasokban, kulonboző periferias szervekben. 3. Az endogen PACAP jelenletet kimutattuk emberi mintakbol biologiai folyadekokban, mint verplazma, anyatej, likvor es konny. A biologiai mintakban előfordulo PACAP merest standardizaltuk, es klinikai allapotok sulyossagaval mertuk ossze szamos pathologias folyamatokban. 4. Leirtuk PACAP genhianyos egerek idegrendszeri fejlődeset. Igazoltuk, hogy PACAP hianyaban az idegrendszer es a periferias szervek is karos behatasokra erzekenyebben reagalnak. A tamogatas segitsegevel szuletett kozlemenyek osszesitett impakt faktora 197,3 (absztraktok nelkul). | Major findings of the present project are: 1. We have shown the involvement of antiapoptotic, antiinflammatory and antioxidant effects in the PACAP-induced neuroprotective and general cytoprotective actions. We have described several signal transduction pathways in the apoptotic process, inflammatory markers and oxidative stress markers upon PACAP treatment. 2. We have described the cytoprotective effects of PACAP in different lesion models in the retina, inner ear, traumatic brain injury, ischemic organ lesions, and in several peripheral organs. 3. We have shown the presence of endogenous PACAP in human biological samples, like blood plasma, breast milk, cerebrospinal fluid and tear fluid. We have standardized the PACAP measurements in biological fluids and we have drawn correlations between PACAP levels and clinical status in several pathological conditions. 4. We have described the nervous development of PACAP knockout mice. We have shown that the lack of PACAP leads to increased vulnerability to different stressors both in the nervous system and in the periphery. The impact factor of peer reviewed papers published with the support of the present grant is 197,3." @default.
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- W953062034 title "A hipofízis adenilát cikláz aktiváló polipeptid (PACAP) neuroprotektív hatásmechanizmusa in vitro és in vivo rendszerekben valamint az endogén PACAP vizsgálata = The mechanism of neuroprotection of pituitary adenylate cyclase activating polypeptide (PACAP) in in vivo and in vitro systems and the examination of endogenous PACAP" @default.
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