Matches in SemOpenAlex for { <https://semopenalex.org/work/W95308341> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W95308341 endingPage "5" @default.
- W95308341 startingPage "601" @default.
- W95308341 abstract "The haemodynamic effect of any drug being the resultant of its myocardial and vascular actions, it is often difficult to separate what is due to each of these components. Dobutamine is regarded as having an almost exclusive effect on the myocardium in therapeutic doses (1); its administration after implantation of an artificial heart would enable its peripheral vascular effects to be determined by exclusion of the native ventricles. Experiments were conducted on three calves weighing about 90 kg each. The artificial heart, two central venous catheters and a femoral arterial catheter were implanted under general anaesthesia. The study began on the first post-implantation day, the animals being awake, in stable haemodynamic status and with normal temperature. Dobutamine was infused through one of the venous catheter placed in the native atrium, in 6 stepwise doses of 5, 10, 15, 20, 25 and 30 mcg/kg/min, each dose being given over 10 min and separated from the other dose by a 10 min interval. The order in which these doses were administered was determined at random. By adjusting the propulsion pressure of the two ventricles and the heart rate, the cardiac output was set at a fixed value of 7.85 L/min throughout the study, this value being controlled by a computer-assisted unit. Right atrial pressure and femoral arterial were recorded during each step of the infusion. Total peripheral resistance was calculated over a stable period of the last 5 min of each dosing and before administration of dobutamine. This procedure was repeated 4 times in each calf, at intervals of 24 hours.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W95308341 created "2016-06-24" @default.
- W95308341 creator A5007131845 @default.
- W95308341 creator A5026889040 @default.
- W95308341 creator A5029489107 @default.
- W95308341 creator A5029718711 @default.
- W95308341 creator A5062386581 @default.
- W95308341 date "1989-04-01" @default.
- W95308341 modified "2023-09-27" @default.
- W95308341 title "[Dose-dependent vasodilator effect of dobutamine in calves with a constant cardiac output artificial heart]." @default.
- W95308341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2500915" @default.
- W95308341 hasPublicationYear "1989" @default.
- W95308341 type Work @default.
- W95308341 sameAs 95308341 @default.
- W95308341 citedByCount "0" @default.
- W95308341 crossrefType "journal-article" @default.
- W95308341 hasAuthorship W95308341A5007131845 @default.
- W95308341 hasAuthorship W95308341A5026889040 @default.
- W95308341 hasAuthorship W95308341A5029489107 @default.
- W95308341 hasAuthorship W95308341A5029718711 @default.
- W95308341 hasAuthorship W95308341A5062386581 @default.
- W95308341 hasConcept C126322002 @default.
- W95308341 hasConcept C139940330 @default.
- W95308341 hasConcept C141071460 @default.
- W95308341 hasConcept C164705383 @default.
- W95308341 hasConcept C178853913 @default.
- W95308341 hasConcept C2777953023 @default.
- W95308341 hasConcept C2781185063 @default.
- W95308341 hasConcept C2781267111 @default.
- W95308341 hasConcept C35207712 @default.
- W95308341 hasConcept C42219234 @default.
- W95308341 hasConcept C58245268 @default.
- W95308341 hasConcept C71924100 @default.
- W95308341 hasConcept C84393581 @default.
- W95308341 hasConceptScore W95308341C126322002 @default.
- W95308341 hasConceptScore W95308341C139940330 @default.
- W95308341 hasConceptScore W95308341C141071460 @default.
- W95308341 hasConceptScore W95308341C164705383 @default.
- W95308341 hasConceptScore W95308341C178853913 @default.
- W95308341 hasConceptScore W95308341C2777953023 @default.
- W95308341 hasConceptScore W95308341C2781185063 @default.
- W95308341 hasConceptScore W95308341C2781267111 @default.
- W95308341 hasConceptScore W95308341C35207712 @default.
- W95308341 hasConceptScore W95308341C42219234 @default.
- W95308341 hasConceptScore W95308341C58245268 @default.
- W95308341 hasConceptScore W95308341C71924100 @default.
- W95308341 hasConceptScore W95308341C84393581 @default.
- W95308341 hasIssue "4" @default.
- W95308341 hasLocation W953083411 @default.
- W95308341 hasOpenAccess W95308341 @default.
- W95308341 hasPrimaryLocation W953083411 @default.
- W95308341 hasRelatedWork W2046617334 @default.
- W95308341 hasRelatedWork W2066758203 @default.
- W95308341 hasRelatedWork W2066853233 @default.
- W95308341 hasRelatedWork W2128445096 @default.
- W95308341 hasRelatedWork W2135912127 @default.
- W95308341 hasRelatedWork W2157926966 @default.
- W95308341 hasRelatedWork W2290202822 @default.
- W95308341 hasRelatedWork W2393128488 @default.
- W95308341 hasRelatedWork W2413668657 @default.
- W95308341 hasRelatedWork W963082253 @default.
- W95308341 hasVolume "82" @default.
- W95308341 isParatext "false" @default.
- W95308341 isRetracted "false" @default.
- W95308341 magId "95308341" @default.
- W95308341 workType "article" @default.