Matches in SemOpenAlex for { <https://semopenalex.org/work/W953189757> ?p ?o ?g. }
- W953189757 abstract "The year 1994 marked the discovery by three independent research groups of a novel mammalian stress-induced kinase (variously named as p38, RK and CSBP), which was subsequently elucidated to be central to a signaling pathway parallel to—but distinct from—the classical growth factor–induced MAP kinase cascade. This discovery, along with the identification of the JNK family of kinases, paved the way for intense research in the molecular and cellular aspects of these important signaling events in health and disease. In the ensuing years, an impressive list of discoveries was made, ranging from the identification of p38 homologues to a detailed understanding of the complex cell-signaling pathways and the biological significance of p38. These findings were facilitated by a pivotal study linking inflammatory cytokine biosynthesis to the p38 pathways using p38 inhibitors as chemical tools. Advances in our understanding of the kinome and other technology platforms have further facilitated the rapid progress in our understanding of p38 MAP kinases as drug targets. This chapter will review important achievements towards the development of p38 kinase inhibitors to treat disease." @default.
- W953189757 created "2016-06-24" @default.
- W953189757 creator A5013425419 @default.
- W953189757 creator A5060399249 @default.
- W953189757 date "2007-01-01" @default.
- W953189757 modified "2023-09-23" @default.
- W953189757 title "PROGRESS IN ACHIEVING PROOF OF CONCEPT FOR p38 KINASE INHIBITORS" @default.
- W953189757 cites W1575030178 @default.
- W953189757 cites W166873479 @default.
- W953189757 cites W1751748906 @default.
- W953189757 cites W1973766879 @default.
- W953189757 cites W1976452827 @default.
- W953189757 cites W1976462601 @default.
- W953189757 cites W1980831535 @default.
- W953189757 cites W1982123744 @default.
- W953189757 cites W1983790923 @default.
- W953189757 cites W1985177300 @default.
- W953189757 cites W2001399809 @default.
- W953189757 cites W2012380734 @default.
- W953189757 cites W2013023341 @default.
- W953189757 cites W2014582878 @default.
- W953189757 cites W2022914311 @default.
- W953189757 cites W2030196438 @default.
- W953189757 cites W2032666422 @default.
- W953189757 cites W2032731042 @default.
- W953189757 cites W2033077711 @default.
- W953189757 cites W2033458490 @default.
- W953189757 cites W2042076664 @default.
- W953189757 cites W2043093261 @default.
- W953189757 cites W2043620856 @default.
- W953189757 cites W2052128932 @default.
- W953189757 cites W2052750950 @default.
- W953189757 cites W2054791134 @default.
- W953189757 cites W2060290661 @default.
- W953189757 cites W2062340794 @default.
- W953189757 cites W2070359381 @default.
- W953189757 cites W2071029740 @default.
- W953189757 cites W2072410510 @default.
- W953189757 cites W2073206600 @default.
- W953189757 cites W2080532845 @default.
- W953189757 cites W2081130105 @default.
- W953189757 cites W2086655427 @default.
- W953189757 cites W2088764696 @default.
- W953189757 cites W2091818624 @default.
- W953189757 cites W2094179447 @default.
- W953189757 cites W2095675477 @default.
- W953189757 cites W2100438302 @default.
- W953189757 cites W2120643436 @default.
- W953189757 cites W2122814011 @default.
- W953189757 cites W2127551467 @default.
- W953189757 cites W2129377911 @default.
- W953189757 cites W2131162745 @default.
- W953189757 cites W2132968779 @default.
- W953189757 cites W2134692718 @default.
- W953189757 cites W2135133228 @default.
- W953189757 cites W2147510335 @default.
- W953189757 cites W2158969445 @default.
- W953189757 cites W2161975618 @default.
- W953189757 cites W2166393142 @default.
- W953189757 doi "https://doi.org/10.1016/b978-012369393-8/50011-0" @default.
- W953189757 hasPublicationYear "2007" @default.
- W953189757 type Work @default.
- W953189757 sameAs 953189757 @default.
- W953189757 citedByCount "1" @default.
- W953189757 countsByYear W9531897572018 @default.
- W953189757 crossrefType "book-chapter" @default.
- W953189757 hasAuthorship W953189757A5013425419 @default.
- W953189757 hasAuthorship W953189757A5060399249 @default.
- W953189757 hasConcept C116834253 @default.
- W953189757 hasConcept C132149769 @default.
- W953189757 hasConcept C184235292 @default.
- W953189757 hasConcept C51551487 @default.
- W953189757 hasConcept C54174078 @default.
- W953189757 hasConcept C59822182 @default.
- W953189757 hasConcept C60644358 @default.
- W953189757 hasConcept C62478195 @default.
- W953189757 hasConcept C70721500 @default.
- W953189757 hasConcept C74187038 @default.
- W953189757 hasConcept C86803240 @default.
- W953189757 hasConcept C95444343 @default.
- W953189757 hasConcept C97029542 @default.
- W953189757 hasConceptScore W953189757C116834253 @default.
- W953189757 hasConceptScore W953189757C132149769 @default.
- W953189757 hasConceptScore W953189757C184235292 @default.
- W953189757 hasConceptScore W953189757C51551487 @default.
- W953189757 hasConceptScore W953189757C54174078 @default.
- W953189757 hasConceptScore W953189757C59822182 @default.
- W953189757 hasConceptScore W953189757C60644358 @default.
- W953189757 hasConceptScore W953189757C62478195 @default.
- W953189757 hasConceptScore W953189757C70721500 @default.
- W953189757 hasConceptScore W953189757C74187038 @default.
- W953189757 hasConceptScore W953189757C86803240 @default.
- W953189757 hasConceptScore W953189757C95444343 @default.
- W953189757 hasConceptScore W953189757C97029542 @default.
- W953189757 hasLocation W9531897571 @default.
- W953189757 hasOpenAccess W953189757 @default.
- W953189757 hasPrimaryLocation W9531897571 @default.
- W953189757 hasRelatedWork W1522113126 @default.
- W953189757 hasRelatedWork W1581236117 @default.
- W953189757 hasRelatedWork W2140788736 @default.