Matches in SemOpenAlex for { <https://semopenalex.org/work/W953351818> ?p ?o ?g. }
- W953351818 endingPage "137" @default.
- W953351818 startingPage "127" @default.
- W953351818 abstract "Innate immunity is central to host defense against fungi. For many types of fungal infections, innate immunity is solely responsible for host defense. However, even for fungal infections that require an adaptive immune response for clearance, innate immunity plays a key role in the effective development of adaptive immunity. Several broad effector mechanisms are induced early to combat a fungal infection. Complement, mannose binding protein (MBP), and surfactant proteins promote initial recognition (opsonization) of fungi. The complement pathways are an essential part of the innate response to fungi. Opsonization can also be mediated by MBP via recognition and binding to complex carbohydrates (e.g., D-mannose and N-acetylglucosamine) on fungal surfaces. During pulmonary infections, surfactant proteins may also opsonize fungi and participate in host defense. The cells of the innate immune system possess many immunoregulatory functions, along with potent antifungal effector mechanisms that can be activated by adaptive immunity. The cells of the innate immune system rapidly release cytokines in response to fungal products and binding of opsonized fungi. Fungal infections induce the production of both C-C and C-X-C chemokines. Dendritic cells are the most effective antigen-presenting cells (APC) for stimulating naive T cells and are probably key APC in initiating Th1-type cellmediated immunity against fungi. Fungal virulence factors and secreted or shed fungal products can interfere with a number of innate mechanisms, resulting in a dynamic interaction between microbe and host." @default.
- W953351818 created "2016-06-24" @default.
- W953351818 creator A5013008945 @default.
- W953351818 creator A5083690478 @default.
- W953351818 date "2014-04-09" @default.
- W953351818 modified "2023-09-23" @default.
- W953351818 title "Innate Immunity and Fungal Infections" @default.
- W953351818 cites W1494526240 @default.
- W953351818 cites W1495215438 @default.
- W953351818 cites W1495915055 @default.
- W953351818 cites W1540756015 @default.
- W953351818 cites W1556118461 @default.
- W953351818 cites W1559339222 @default.
- W953351818 cites W1586347655 @default.
- W953351818 cites W1599978671 @default.
- W953351818 cites W1600813584 @default.
- W953351818 cites W1603746882 @default.
- W953351818 cites W1612465238 @default.
- W953351818 cites W1631903144 @default.
- W953351818 cites W1637364976 @default.
- W953351818 cites W1802820735 @default.
- W953351818 cites W1825194216 @default.
- W953351818 cites W1874479041 @default.
- W953351818 cites W1887755235 @default.
- W953351818 cites W1906710068 @default.
- W953351818 cites W1915436943 @default.
- W953351818 cites W1923143725 @default.
- W953351818 cites W1929259612 @default.
- W953351818 cites W1948394619 @default.
- W953351818 cites W1963286479 @default.
- W953351818 cites W1965917942 @default.
- W953351818 cites W1968595840 @default.
- W953351818 cites W1974660023 @default.
- W953351818 cites W1984272793 @default.
- W953351818 cites W1985530448 @default.
- W953351818 cites W1999503821 @default.
- W953351818 cites W2008831989 @default.
- W953351818 cites W2029693527 @default.
- W953351818 cites W2029713274 @default.
- W953351818 cites W2031528938 @default.
- W953351818 cites W2034021295 @default.
- W953351818 cites W2034124899 @default.
- W953351818 cites W2037884923 @default.
- W953351818 cites W2041200595 @default.
- W953351818 cites W2042123178 @default.
- W953351818 cites W2047329367 @default.
- W953351818 cites W2050594560 @default.
- W953351818 cites W2058894435 @default.
- W953351818 cites W2061277736 @default.
- W953351818 cites W2062949290 @default.
- W953351818 cites W2070550149 @default.
- W953351818 cites W2075438517 @default.
- W953351818 cites W2081058386 @default.
- W953351818 cites W2092296681 @default.
- W953351818 cites W2092540406 @default.
- W953351818 cites W2097139602 @default.
- W953351818 cites W2097684304 @default.
- W953351818 cites W2099026867 @default.
- W953351818 cites W2099568670 @default.
- W953351818 cites W2100437682 @default.
- W953351818 cites W2105191684 @default.
- W953351818 cites W2108140148 @default.
- W953351818 cites W2111657224 @default.
- W953351818 cites W2114239632 @default.
- W953351818 cites W2115009317 @default.
- W953351818 cites W2119182059 @default.
- W953351818 cites W2123412033 @default.
- W953351818 cites W2125108598 @default.
- W953351818 cites W2127330103 @default.
- W953351818 cites W2127537536 @default.
- W953351818 cites W2128103629 @default.
- W953351818 cites W2129710186 @default.
- W953351818 cites W2130313539 @default.
- W953351818 cites W2130882795 @default.
- W953351818 cites W2131563799 @default.
- W953351818 cites W2131818384 @default.
- W953351818 cites W2137175361 @default.
- W953351818 cites W2139205960 @default.
- W953351818 cites W2139455129 @default.
- W953351818 cites W2140883963 @default.
- W953351818 cites W2144566133 @default.
- W953351818 cites W2145843306 @default.
- W953351818 cites W2151277498 @default.
- W953351818 cites W2151788046 @default.
- W953351818 cites W2152025427 @default.
- W953351818 cites W2155345249 @default.
- W953351818 cites W2155595127 @default.
- W953351818 cites W2168730710 @default.
- W953351818 cites W2170170457 @default.
- W953351818 cites W2171219043 @default.
- W953351818 cites W2342768033 @default.
- W953351818 cites W2415495342 @default.
- W953351818 cites W4210875411 @default.
- W953351818 cites W4251130661 @default.
- W953351818 cites W4313310013 @default.
- W953351818 cites W4313335828 @default.
- W953351818 cites W4313342450 @default.
- W953351818 cites W4313347792 @default.