Matches in SemOpenAlex for { <https://semopenalex.org/work/W953473434> ?p ?o ?g. }
- W953473434 endingPage "e0132852" @default.
- W953473434 startingPage "e0132852" @default.
- W953473434 abstract "Iron is an essential chemical element for human life. However, in some pathological conditions, such as hereditary hemochromatosis type 1 (HH1), iron overload induces the production of reactive oxygen species that may lead to lipid peroxidation and a change in the plasma-membrane lipid profile. In this study, we investigated whether iron overload interferes with the Na,K-ATPase activity of the plasma membrane by studying erythrocytes that were obtained from the whole blood of patients suffering from iron overload. Additionally, we treated erythrocytes of normal subjects with 0.8 mM H2O2 and 1 μM FeCl3 for 24 h. We then analyzed the lipid profile, lipid peroxidation and Na,K-ATPase activity of plasma membranes derived from these cells. Iron overload was more frequent in men (87.5%) than in women and was associated with an increase (446%) in lipid peroxidation, as indicated by the amount of the thiobarbituric acid reactive substances (TBARS) and an increase (327%) in the Na,K-ATPase activity in the plasma membrane of erythrocytes. Erythrocytes treated with 1 μM FeCl3 for 24 h showed an increase (132%) in the Na,K-ATPase activity but no change in the TBARS levels. Iron treatment also decreased the cholesterol and phospholipid content of the erythrocyte membranes and similar decreases were observed in iron overload patients. In contrast, erythrocytes treated with 0.8 mM H2O2 for 24 h showed no change in the measured parameters. These results indicate that erythrocytes from patients with iron overload exhibit higher Na,K-ATPase activity compared with normal subjects and that this effect is specifically associated with altered iron levels." @default.
- W953473434 created "2016-06-24" @default.
- W953473434 creator A5005640305 @default.
- W953473434 creator A5006978350 @default.
- W953473434 creator A5012407672 @default.
- W953473434 creator A5037973130 @default.
- W953473434 creator A5041767886 @default.
- W953473434 creator A5047057839 @default.
- W953473434 creator A5047951594 @default.
- W953473434 creator A5052077736 @default.
- W953473434 creator A5057669342 @default.
- W953473434 creator A5081260424 @default.
- W953473434 creator A5086875894 @default.
- W953473434 date "2015-07-21" @default.
- W953473434 modified "2023-10-18" @default.
- W953473434 title "Effects of Iron Overload on the Activity of Na,K-ATPase and Lipid Profile of the Human Erythrocyte Membrane" @default.
- W953473434 cites W1431418 @default.
- W953473434 cites W1525515545 @default.
- W953473434 cites W1549872517 @default.
- W953473434 cites W1557224032 @default.
- W953473434 cites W1590457525 @default.
- W953473434 cites W1963797525 @default.
- W953473434 cites W1979397737 @default.
- W953473434 cites W1980861782 @default.
- W953473434 cites W1981757167 @default.
- W953473434 cites W1985342306 @default.
- W953473434 cites W1985533627 @default.
- W953473434 cites W198783759 @default.
- W953473434 cites W1987991320 @default.
- W953473434 cites W1988331045 @default.
- W953473434 cites W1988517559 @default.
- W953473434 cites W1993226322 @default.
- W953473434 cites W1995522998 @default.
- W953473434 cites W1996395796 @default.
- W953473434 cites W2000630012 @default.
- W953473434 cites W2007360886 @default.
- W953473434 cites W2010285535 @default.
- W953473434 cites W2012398605 @default.
- W953473434 cites W2014516383 @default.
- W953473434 cites W2017074521 @default.
- W953473434 cites W2019411447 @default.
- W953473434 cites W2019680585 @default.
- W953473434 cites W2023482799 @default.
- W953473434 cites W2025730963 @default.
- W953473434 cites W2038601041 @default.
- W953473434 cites W2047018225 @default.
- W953473434 cites W2053304292 @default.
- W953473434 cites W2056818500 @default.
- W953473434 cites W2059496396 @default.
- W953473434 cites W2059854143 @default.
- W953473434 cites W2061075360 @default.
- W953473434 cites W2062156420 @default.
- W953473434 cites W2067937824 @default.
- W953473434 cites W2068109198 @default.
- W953473434 cites W2069300674 @default.
- W953473434 cites W2083448771 @default.
- W953473434 cites W2089818043 @default.
- W953473434 cites W2089832642 @default.
- W953473434 cites W2097013679 @default.
- W953473434 cites W2103584701 @default.
- W953473434 cites W2107514345 @default.
- W953473434 cites W2107872932 @default.
- W953473434 cites W2116565080 @default.
- W953473434 cites W2120421235 @default.
- W953473434 cites W2124377321 @default.
- W953473434 cites W2127462691 @default.
- W953473434 cites W2132662127 @default.
- W953473434 cites W2133772124 @default.
- W953473434 cites W2135887696 @default.
- W953473434 cites W2141972986 @default.
- W953473434 cites W2142048790 @default.
- W953473434 cites W2144648585 @default.
- W953473434 cites W2147782690 @default.
- W953473434 cites W2148688997 @default.
- W953473434 cites W2148962258 @default.
- W953473434 cites W2151094171 @default.
- W953473434 cites W2153435210 @default.
- W953473434 cites W2162153512 @default.
- W953473434 cites W2168047437 @default.
- W953473434 cites W2168051647 @default.
- W953473434 cites W2170176251 @default.
- W953473434 cites W2186595494 @default.
- W953473434 cites W2435165373 @default.
- W953473434 cites W2461433575 @default.
- W953473434 cites W3885546 @default.
- W953473434 cites W4214949414 @default.
- W953473434 doi "https://doi.org/10.1371/journal.pone.0132852" @default.
- W953473434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4510300" @default.
- W953473434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26197432" @default.
- W953473434 hasPublicationYear "2015" @default.
- W953473434 type Work @default.
- W953473434 sameAs 953473434 @default.
- W953473434 citedByCount "23" @default.
- W953473434 countsByYear W9534734342016 @default.
- W953473434 countsByYear W9534734342017 @default.
- W953473434 countsByYear W9534734342018 @default.
- W953473434 countsByYear W9534734342019 @default.
- W953473434 countsByYear W9534734342020 @default.