FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W95352016> ?p ?o ?g. }

• W95352016 abstract "Risk stratification and identification of those patients with hypertrophic cardiomyopathy (HCM) at the highest risk for sudden death is a major issue for patient management, given the effective option of the implantable defibrillator in this disease. For example, the prognostic significance of syncope has not been investigated systematically in large HCM cohorts, and therefore treatment strategies related to this symptom have been based largely on intuition and experience. We assessed the relationship between syncope and sudden death in 1511 consecutive HCM patients. Unexplained (n=153) or neurally-mediated (n=52) syncope occurred in 205 (14%) of patients. Over a 5.6±5.2 year follow-up, 74 patients died suddenly. Relative risk of sudden death was 1.78 (95% CI 0.88 –3.51; p=0.08) in patients with unexplained syncope, and 0.91 (95% CI 0.00 –3.83; p=1.0) in those with neurally-mediated syncope, compared to patients without syncope. However, the time interval between unexplained syncope and initial patient evaluation proved to have a strong impact on sudden death risk. Patients with recent syncope (≤6 months from initial evaluation) showed a 5-fold increase in risk compared to patients without syncope (adjusted HR=4.89; CI 2.19 –10.94; p=0.006), a relationship maintained throughout all age groups (<18, 18 –39 and ≥40 years). Conversely, adult patients (18 –39 and ≥40 years) with remote syncope (>6 months from evaluation) showed no increase in sudden death rate (4.8; 95% CI 0.1–26.7 and 3.2; 95% CI 0.1–17.8 per 1000 person-years, respectively), compared to patients of similar age without syncope (11.8; 95% CI 7.6 –17.6 and 5.7%; 95% CI 3.8 – 8.3 per 1000 person-years). Left ventricular outflow obstruction was not associated with sudden death risk (p=0.29). In this large HCM cohort, unexplained syncope proved to be a risk factor for sudden death. In addition, the temporal proximity of syncopal events to patient evaluation is of clinical relevance. Recent unexplained syncope is associated with an increased risk for sudden death in all age groups, while remote syncopal events do not convey increased risk to adult patients." @default.
• W95352016 created "2016-06-24" @default.
• W95352016 creator A5002142014 @default.
• W95352016 creator A5005294349 @default.
• W95352016 creator A5011814572 @default.
• W95352016 creator A5019872175 @default.
• W95352016 creator A5026665975 @default.
• W95352016 creator A5048131213 @default.
• W95352016 creator A5050553761 @default.
• W95352016 creator A5055362368 @default.
• W95352016 creator A5058059684 @default.
• W95352016 creator A5065775977 @default.
• W95352016 creator A5072602518 @default.
• W95352016 creator A5077454613 @default.
• W95352016 creator A5078231013 @default.
• W95352016 creator A5086212438 @default.
• W95352016 creator A5091096142 @default.
• W95352016 date "2008-10-28" @default.
• W95352016 modified "2023-09-26" @default.
• W95352016 title "Abstract 4683: Risk Stratification in Hypertrophic Cardiomyopathy: Evidence that Syncope is a Marker for Sudden Death" @default.
• W95352016 doi "https://doi.org/10.1161/circ.118.suppl_18.s_929-b" @default.
• W95352016 hasPublicationYear "2008" @default.
• W95352016 type Work @default.
• W95352016 sameAs 95352016 @default.
• W95352016 citedByCount "0" @default.
• W95352016 crossrefType "journal-article" @default.
• W95352016 hasAuthorship W95352016A5002142014 @default.
• W95352016 hasAuthorship W95352016A5005294349 @default.
• W95352016 hasAuthorship W95352016A5011814572 @default.
• W95352016 hasAuthorship W95352016A5019872175 @default.
• W95352016 hasAuthorship W95352016A5026665975 @default.
• W95352016 hasAuthorship W95352016A5048131213 @default.
• W95352016 hasAuthorship W95352016A5050553761 @default.
• W95352016 hasAuthorship W95352016A5055362368 @default.
• W95352016 hasAuthorship W95352016A5058059684 @default.
• W95352016 hasAuthorship W95352016A5065775977 @default.
• W95352016 hasAuthorship W95352016A5072602518 @default.
• W95352016 hasAuthorship W95352016A5077454613 @default.
• W95352016 hasAuthorship W95352016A5078231013 @default.
• W95352016 hasAuthorship W95352016A5086212438 @default.
• W95352016 hasAuthorship W95352016A5091096142 @default.
• W95352016 hasConcept C126322002 @default.
• W95352016 hasConcept C164705383 @default.
• W95352016 hasConcept C2775935837 @default.
• W95352016 hasConcept C2780074459 @default.
• W95352016 hasConcept C2780185194 @default.
• W95352016 hasConcept C2780703726 @default.
• W95352016 hasConcept C2993353509 @default.
• W95352016 hasConcept C3020404979 @default.
• W95352016 hasConcept C71924100 @default.
• W95352016 hasConceptScore W95352016C126322002 @default.
• W95352016 hasConceptScore W95352016C164705383 @default.
• W95352016 hasConceptScore W95352016C2775935837 @default.
• W95352016 hasConceptScore W95352016C2780074459 @default.
• W95352016 hasConceptScore W95352016C2780185194 @default.
• W95352016 hasConceptScore W95352016C2780703726 @default.
• W95352016 hasConceptScore W95352016C2993353509 @default.
• W95352016 hasConceptScore W95352016C3020404979 @default.
• W95352016 hasConceptScore W95352016C71924100 @default.
• W95352016 hasIssue "suppl_18" @default.
• W95352016 hasLocation W953520161 @default.
• W95352016 hasOpenAccess W95352016 @default.
• W95352016 hasPrimaryLocation W953520161 @default.
• W95352016 hasRelatedWork W2009491928 @default.
• W95352016 hasRelatedWork W2040297507 @default.
• W95352016 hasRelatedWork W2047704128 @default.
• W95352016 hasRelatedWork W2327845348 @default.
• W95352016 hasRelatedWork W2414414561 @default.
• W95352016 hasRelatedWork W2469163198 @default.
• W95352016 hasRelatedWork W2795282080 @default.
• W95352016 hasRelatedWork W2999928784 @default.
• W95352016 hasRelatedWork W3166975958 @default.
• W95352016 hasRelatedWork W4307303983 @default.
• W95352016 hasVolume "118" @default.
• W95352016 isParatext "false" @default.
• W95352016 isRetracted "false" @default.
• W95352016 magId "95352016" @default.
• W95352016 workType "article" @default.