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- W95366129 abstract "Abstract pathogen-associated molecular patterns (PAMP) are recognized by Toll-like receptors (TLR) and C-type lectin recptors including Dectin-1. Previously, we indicated that neither TLR2 nor TLR4 was involved in the host defence to infection with Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients (FEMS Immunol. Med. Microbiol. 47: 148–154, 2006). In the current study, we examined the role of Dectin-1, a receptor for β-glucan, in this response. Dectin-1-deficient mice were resistant to intratracheal and intravenous infection with C. neoformans at a comparable level to wild-type mice. IFN-γ production in lung an serum was not largely different between these mice. There was not significant difference in the synthesis of IL-12p40 and TNF-α by bone marrow-derived dendritic cells upon stimulation with this fungal pathogen. Taken together, these results demonstrated that Dectin-1 did not play a major role in the host protective responses to C. neoformans infection. This work was supported in part by a Grant-in -Aid for Science Research (C) (KAKENHI18590413) from the Ministry of Education, Culture, Sports, Science and Technology and by Tohoku University 21st COE program ′CRESCENDO′" @default.
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- W95366129 date "2007-04-01" @default.
- W95366129 modified "2023-10-18" @default.
- W95366129 title "Role of dectin-1 in the host defense to infection with <i>Cryptococcus neoformans</i> (44.17)" @default.
- W95366129 doi "https://doi.org/10.4049/jimmunol.178.supp.44.17" @default.
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