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- W953676178 abstract "目的：检测胃癌组织中Her-2／neu，Syndecan-1表达情况，探讨二者在胃癌发生发展及侵袭、转移中的作用。方法：应用免疫组化sP法检测112例胃癌组织及40例正常胃粘膜中Her-2／neu，Syndecan-1表达。结果：①112例胃癌组织和40例正常胃粘膜中Her-2／neu阳性表达率分别为20．5％和5％，Syndecan-1阳性表达率分别为46．4％和100．0％。胃癌组织Her-2／neu阳性表达率显著高于正常胃粘膜阳性表达率（X^2=5．17，P〈0．05），正常胃粘膜Syndecan-1阳性表达率显著高于胃癌组织（X^2=20．80，P〈0．01）；②胃癌组织Her-2／neu的表达与胃癌分化程度（X^2=4．82，P〈0．05），TNM分期（X^2=5．37，P〈0．05）、淋巴结转移多少（X^2=6．42，P〈0．05）及浆膜浸润（X^2=7．30，P〈0．01）均显著相关；③胃癌组织Syndecan-1的表达与胃癌分化程度、淋巴结转移呈负相关（X^2=11．83，P〈0．01和X^2=13．74，P〈0．01）；④胃癌组织中Her-2／neu阳性表达与Syndeean-1的阴性表达显著相关（X^2=14．25，P〈0．01）。结论：①Her-2／neu高表达显示胃癌恶性程度高、分期晚、预后不良；②Syndecan-1属保护性因素，在恶性程度高、分期晚的患者中表达降低；③Her-2／neu阳性表达的胃癌组织中Syndecan-1的表达降低。" @default.
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- W953676178 date "2006-09-24" @default.
- W953676178 modified "2023-09-24" @default.
- W953676178 title "Her-2/neu,Syndecan-1在胃癌中的表达及意义" @default.
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