Matches in SemOpenAlex for { <https://semopenalex.org/work/W953831877> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W953831877 endingPage "328" @default.
- W953831877 startingPage "325" @default.
- W953831877 abstract "To study the effect of simulated ischemia-reperfusion (I/R) on If of sinoatrial node (SAN) cellsand the ntervention of KATP channel opener Pinacidil. Methods: The SAN cells of the neonatal rats were detached and pu-rified 2 d efore the experiment. The experimental animals were randomly divided into the control group, group of simulatedI/R, group intervened with KATP channel opener Pinacidil (P + I/R) and group intervened with KATP channel blockingagent 5-HD (5-HD + P + I/R & 5-HD + I/R). The If density of each group was measured by technique of routine whole elldifferent directive potentials, the If density of the SAN cells in I/R group increased significantly, compared with that in thecontrol group ( P ＜ 0.01 ); that in P + I/R group decreased significantly, compared with that in I/R group ( P ＜ 0.01 ); theIf density values in 5-HD + P + I/R group and 5-HD + I/R group increased significantly, compared with that in P + I/Red curve of the SAN cells moved rightwards under ultimate activating potential, half of which was from - 108.0 ± 12.4 to- 89.5 ± 7.2 mV ( P ＜ 0.01 ); compared with that in I/R group, If activated curve of the SAN cells moved leftwards underultimate activating potential, half of which was the range from - 99.5 ± 10.8 mV ( P ＜ 0.05 ); KATP channel blockingagent 5-HD could block the effect of Pinacdil on If activated curve. Conclusion: KATP channel opener Pinacidil can antago-nize the effect of simulated I/R on the If of SAN cells, which may be beneficial to the maintenance of the relative stability ofion steady state and electrophysiological activities under condition of simulated I/R." @default.
- W953831877 created "2016-06-24" @default.
- W953831877 creator A5036481456 @default.
- W953831877 creator A5049379854 @default.
- W953831877 creator A5052688503 @default.
- W953831877 date "2004-01-01" @default.
- W953831877 modified "2023-09-26" @default.
- W953831877 title "Effect of simulated ischemia-reperfusion on If in sinoatrial node cells and theintervention of KATP channel opener" @default.
- W953831877 hasPublicationYear "2004" @default.
- W953831877 type Work @default.
- W953831877 sameAs 953831877 @default.
- W953831877 citedByCount "0" @default.
- W953831877 crossrefType "journal-article" @default.
- W953831877 hasAuthorship W953831877A5036481456 @default.
- W953831877 hasAuthorship W953831877A5049379854 @default.
- W953831877 hasAuthorship W953831877A5052688503 @default.
- W953831877 hasConcept C126322002 @default.
- W953831877 hasConcept C127413603 @default.
- W953831877 hasConcept C134018914 @default.
- W953831877 hasConcept C164705383 @default.
- W953831877 hasConcept C201289731 @default.
- W953831877 hasConcept C2775845273 @default.
- W953831877 hasConcept C2775984225 @default.
- W953831877 hasConcept C2777194220 @default.
- W953831877 hasConcept C2777953023 @default.
- W953831877 hasConcept C2778542873 @default.
- W953831877 hasConcept C2779768347 @default.
- W953831877 hasConcept C42219234 @default.
- W953831877 hasConcept C541997718 @default.
- W953831877 hasConcept C555293320 @default.
- W953831877 hasConcept C71924100 @default.
- W953831877 hasConcept C78519656 @default.
- W953831877 hasConcept C83743174 @default.
- W953831877 hasConcept C84393581 @default.
- W953831877 hasConceptScore W953831877C126322002 @default.
- W953831877 hasConceptScore W953831877C127413603 @default.
- W953831877 hasConceptScore W953831877C134018914 @default.
- W953831877 hasConceptScore W953831877C164705383 @default.
- W953831877 hasConceptScore W953831877C201289731 @default.
- W953831877 hasConceptScore W953831877C2775845273 @default.
- W953831877 hasConceptScore W953831877C2775984225 @default.
- W953831877 hasConceptScore W953831877C2777194220 @default.
- W953831877 hasConceptScore W953831877C2777953023 @default.
- W953831877 hasConceptScore W953831877C2778542873 @default.
- W953831877 hasConceptScore W953831877C2779768347 @default.
- W953831877 hasConceptScore W953831877C42219234 @default.
- W953831877 hasConceptScore W953831877C541997718 @default.
- W953831877 hasConceptScore W953831877C555293320 @default.
- W953831877 hasConceptScore W953831877C71924100 @default.
- W953831877 hasConceptScore W953831877C78519656 @default.
- W953831877 hasConceptScore W953831877C83743174 @default.
- W953831877 hasConceptScore W953831877C84393581 @default.
- W953831877 hasIssue "6" @default.
- W953831877 hasLocation W9538318771 @default.
- W953831877 hasOpenAccess W953831877 @default.
- W953831877 hasPrimaryLocation W9538318771 @default.
- W953831877 hasRelatedWork W1033945838 @default.
- W953831877 hasRelatedWork W1964502938 @default.
- W953831877 hasRelatedWork W2092762304 @default.
- W953831877 hasRelatedWork W2103659193 @default.
- W953831877 hasRelatedWork W2221672336 @default.
- W953831877 hasRelatedWork W2394883531 @default.
- W953831877 hasRelatedWork W2397642262 @default.
- W953831877 hasRelatedWork W2398507658 @default.
- W953831877 hasRelatedWork W2405056447 @default.
- W953831877 hasRelatedWork W2409349666 @default.
- W953831877 hasRelatedWork W2410970754 @default.
- W953831877 hasRelatedWork W2417234804 @default.
- W953831877 hasRelatedWork W2580151406 @default.
- W953831877 hasRelatedWork W2584632798 @default.
- W953831877 hasRelatedWork W2802846892 @default.
- W953831877 hasRelatedWork W3031872792 @default.
- W953831877 hasRelatedWork W3031884875 @default.
- W953831877 hasRelatedWork W3032223099 @default.
- W953831877 hasRelatedWork W3048996748 @default.
- W953831877 hasRelatedWork W3172813125 @default.
- W953831877 hasVolume "19" @default.
- W953831877 isParatext "false" @default.
- W953831877 isRetracted "false" @default.
- W953831877 magId "953831877" @default.
- W953831877 workType "article" @default.