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- W953875711 abstract "Publisher Summary This chapter discusses strategies to target chemotherapeutics tumors. Targeted chemotherapies employ prodrug strategies designed to selectively deposit the active metabolite in tumor tissue. For these approaches to increase the therapeutic index of the active metabolite, the prodrug must be selectively activated in the tumor and the active metabolite must remain in the tumor for a reasonable time relative to the time it takes for the drug to trigger cell death. Early efforts to target chemotherapeutics to tumors used antibody-directed enzyme prodrug technique (ADEPT). The potential antigenicity of the antibody–enzyme conjugate, the specificity of the antibody for tumor cells, and problems in distributing macromolecules throughout tumors are additional complexities with the ADEPT approach. The plasma-membrane association of cathepsin B correlates with the experimental metastatic potential of the tumor cells. It is found that TMPRSS2, TMPRSS3, and hepsin are overexpressed in prostate, pancreatic, and ovarian tumors, respectively. Matripase was found primarily without its kunitz-type inhibitor in some breast cancer lines, which suggested that matripase activity is elevated in breast cancer. It is suggested that genomic information and mRNA expression profiling may identify new tumor-elevated antigens and enzymes that broaden the applicability of these approaches." @default.
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- W953875711 date "2006-01-01" @default.
- W953875711 modified "2023-10-16" @default.
- W953875711 title "STRATEGIES TO TARGET CHEMOTHERAPEUTICS TO TUMORS" @default.
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- W953875711 doi "https://doi.org/10.1016/b978-012088561-9/50004-1" @default.
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