Matches in SemOpenAlex for { <https://semopenalex.org/work/W95395536> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W95395536 endingPage "31" @default.
- W95395536 startingPage "225" @default.
- W95395536 abstract "Serum phosphate is maintained within a certain range by intestinal phosphate absorption, renal phosphate handling, and dynamic equilibrium with the intracellular phosphate or phosphate in bone. Of these, renal phosphate handling is believed to be the main determinant of the serum phosphate level at least in a chronic state. Most of the phosphate filtered from the glomeruli is reabsorbed in proximal tubules through type 2a and 2c sodium-phosphate co-transporters. Therefore, chronic hypophosphatemia and hyperphosphatemia are usually caused by changes in renal phosphate handling. Several humoral factors, including parathyroid hormone and insulin-like growth factor-I, have been known to affect proximal tubular phosphate reabsorption. In addition, fibroblast growth factor 23 (FGF23) was shown to inhibit phosphate reabsorption by suppressing the expression of type 2a and 2c sodium-phosphate co-transporters. FGF23 also reduces the circulatory 1,25-dihydroxyvitamin D [1,25 (OH)2D] level. FGF23 is produced by bone, especially by osteocytes, and works in the kidney by binding to the Klotho-FGF receptor complex. It has been shown that excess actions of FGF23 cause several kinds of hypophosphatemic rickets/osteomalacia with impaired proximal tubular phosphate reabsorption and a rather low 1,25 (OH)2D level. In contrast, deficient actions of FGF23 result in familial hyperphosphatemic tumoral calcinosis with enhanced proximal tubular phosphate reabsorption and high 1,25 (OH)2D. These results indicate that FGF23 is a hormone regulating phosphate and vitamin D metabolism. In addition, several hypophosphatemic and hyperphosphatemic diseases can be classified as endocrine diseases caused by the aberrant actions of FGF23. It is possible that some drugs that modulate the action of FGF23 can be novel therapeutic measures for abnormal phosphate metabolism in the future." @default.
- W95395536 created "2016-06-24" @default.
- W95395536 creator A5002923621 @default.
- W95395536 date "2010-03-01" @default.
- W95395536 modified "2023-09-29" @default.
- W95395536 title "[Disorders of phosphate metabolism]." @default.
- W95395536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20408440" @default.
- W95395536 hasPublicationYear "2010" @default.
- W95395536 type Work @default.
- W95395536 sameAs 95395536 @default.
- W95395536 citedByCount "0" @default.
- W95395536 crossrefType "journal-article" @default.
- W95395536 hasAuthorship W95395536A5002923621 @default.
- W95395536 hasConcept C114276007 @default.
- W95395536 hasConcept C124490489 @default.
- W95395536 hasConcept C126322002 @default.
- W95395536 hasConcept C134018914 @default.
- W95395536 hasConcept C185592680 @default.
- W95395536 hasConcept C2776036575 @default.
- W95395536 hasConcept C2776079296 @default.
- W95395536 hasConcept C2776489590 @default.
- W95395536 hasConcept C2777132085 @default.
- W95395536 hasConcept C2778049618 @default.
- W95395536 hasConcept C2778573388 @default.
- W95395536 hasConcept C2780091579 @default.
- W95395536 hasConcept C2781208988 @default.
- W95395536 hasConcept C2911197707 @default.
- W95395536 hasConcept C519063684 @default.
- W95395536 hasConcept C55493867 @default.
- W95395536 hasConcept C56906281 @default.
- W95395536 hasConcept C71924100 @default.
- W95395536 hasConcept C86803240 @default.
- W95395536 hasConcept C9832595 @default.
- W95395536 hasConceptScore W95395536C114276007 @default.
- W95395536 hasConceptScore W95395536C124490489 @default.
- W95395536 hasConceptScore W95395536C126322002 @default.
- W95395536 hasConceptScore W95395536C134018914 @default.
- W95395536 hasConceptScore W95395536C185592680 @default.
- W95395536 hasConceptScore W95395536C2776036575 @default.
- W95395536 hasConceptScore W95395536C2776079296 @default.
- W95395536 hasConceptScore W95395536C2776489590 @default.
- W95395536 hasConceptScore W95395536C2777132085 @default.
- W95395536 hasConceptScore W95395536C2778049618 @default.
- W95395536 hasConceptScore W95395536C2778573388 @default.
- W95395536 hasConceptScore W95395536C2780091579 @default.
- W95395536 hasConceptScore W95395536C2781208988 @default.
- W95395536 hasConceptScore W95395536C2911197707 @default.
- W95395536 hasConceptScore W95395536C519063684 @default.
- W95395536 hasConceptScore W95395536C55493867 @default.
- W95395536 hasConceptScore W95395536C56906281 @default.
- W95395536 hasConceptScore W95395536C71924100 @default.
- W95395536 hasConceptScore W95395536C86803240 @default.
- W95395536 hasConceptScore W95395536C9832595 @default.
- W95395536 hasIssue "3" @default.
- W95395536 hasLocation W953955361 @default.
- W95395536 hasOpenAccess W95395536 @default.
- W95395536 hasPrimaryLocation W953955361 @default.
- W95395536 hasRelatedWork W1494413028 @default.
- W95395536 hasRelatedWork W188132638 @default.
- W95395536 hasRelatedWork W189713244 @default.
- W95395536 hasRelatedWork W2036702993 @default.
- W95395536 hasRelatedWork W2046286100 @default.
- W95395536 hasRelatedWork W2073926011 @default.
- W95395536 hasRelatedWork W2108037207 @default.
- W95395536 hasRelatedWork W2161630557 @default.
- W95395536 hasRelatedWork W2297047812 @default.
- W95395536 hasRelatedWork W2346034098 @default.
- W95395536 hasRelatedWork W2406189743 @default.
- W95395536 hasRelatedWork W2407844531 @default.
- W95395536 hasRelatedWork W2412665752 @default.
- W95395536 hasRelatedWork W2790748016 @default.
- W95395536 hasRelatedWork W2794753378 @default.
- W95395536 hasRelatedWork W2909879195 @default.
- W95395536 hasRelatedWork W2991813372 @default.
- W95395536 hasRelatedWork W36137382 @default.
- W95395536 hasRelatedWork W599137002 @default.
- W95395536 hasRelatedWork W650197036 @default.
- W95395536 hasVolume "58" @default.
- W95395536 isParatext "false" @default.
- W95395536 isRetracted "false" @default.
- W95395536 magId "95395536" @default.
- W95395536 workType "article" @default.