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- W953973070 abstract "【Objective】 To investigate the inhibition effects of IFN-γ on TNF-α promoted collagen biosynthesis of oral submucous fibrosis (OSF)-derived fibroblasts. 【Methods】 Fibroblast cultures were established from the buccal mucosa of five normal persons and six patients with OSF. The study focused on the effects of IFN-γ on the collagen biosynthesis of fibroblasts by TNF-α promoted in vitro. Also the changes of the ultrastructure were observed by electronmicroscopy. 【Results】 The study showed that IFN-γ could reduce the TNF-αpromoted collagen biosynthesis of oral mucosal-derived fibroblasts. 【Conclusions】 The investigation confirm that IFN-γ is a cytokine with down-regulation effects on OSF progression, and suggest that IFN-γ can play an important role in prevention and treatment of OSF." @default.
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- W953973070 date "2006-06-15" @default.
- W953973070 modified "2023-09-23" @default.
- W953973070 title "γ-干扰素对肿瘤坏死因子-α促口腔黏膜下纤维化成纤维细胞胶原合成的抑制作用" @default.
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