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- W95400258 abstract "Abstract Ribosomes continue to function, very slowly, in the presence of high concentrations of fusidic acid in , vivo . Initially, the drug confines nascent peptides to the ribosomal P sites by inhibiting the binding of aminoacyl-tRNA into the A sites. Subsequently, the nascent peptides gradually escape from the P sites and a slow cycle is established in which the peptides enter and leave both ribosomal sites. At this stage fusidic acid also inhibits translocation. We have attempted to rationalize these findings in terms of interaction between fusidic acid, guanine nucleotides and elongation factors at a single ribosomal locus." @default.
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- W95400258 date "1972-11-01" @default.
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- W95400258 title "Long term effects of fusidic acid on bacterial protein synthesis in,vivo" @default.
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- W95400258 doi "https://doi.org/10.1016/0006-291x(72)90477-9" @default.
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