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- W954105887 abstract "Objective To investigate the relationship between G894T polymorphism of endothelial nitric oxide synthase(eNOS) gene and essential hypertension(EH)in Dongxiang minority population.Methods The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was used to detect genetypes of eNOS gene exon 7th G894T of patients with essential hypertensive(EH),whose nitric oxide metabolites(NOM)were measured by nitrate reductase.Normotensives(NT)people consisted of the control group.Results eNOS gene G894T polymorphism was in line with the Hardy-Weinberg banlanced law.The frequencies of GT + TT genotypes and T allele in EH were higher than those in NT respectively(P0.05 or P0.01).SBP,DBP and MBP of patients with T allele of eNOS gene G894T polymorphism were higher than those of patiengts with GG genotype respectively(P0.05).The level of NOm was lower in GT+TT genotypes than that in GG genotype(P0.05).Conclusions eNOS gene exon 7th G894T polymorphism is associated with EH in Dongxiang minority population.T allele may be involved in the aetiology of EH by reducing NO release of endothelium." @default.
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- W954105887 date "2009-01-01" @default.
- W954105887 modified "2023-09-23" @default.
- W954105887 title "Relationship between G894T polymorphism of endothelial nitric oxide synthase gene and essential hypertension in dongxiang minority population." @default.
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