Matches in SemOpenAlex for { <https://semopenalex.org/work/W954319650> ?p ?o ?g. }
- W954319650 endingPage "239" @default.
- W954319650 startingPage "215" @default.
- W954319650 abstract "A large body of clinical and experimental studies implicates free radical mechanisms in the pathogenesis of alcoholic liver disease (ALD). Ethanol-induced oxidative stress is the result of the combined impairment of antioxidant defenses and the stimulation of reactive oxygen species (ROS) production by the mitochondrial electron transport chain, the alcohol-inducible cytochrome P4502E1 (CYP2E1), and activated phagocytes. Furthermore, hydroxyethyl free radicals (HER) are also generated during ethanol metabolism by CYP2E1. The mechanisms by which oxidative stress contributes to alcohol toxicity involve mitochondrial permeability transition, endoplasmic reticulum stress, and impairment of hepatocyte pro-survival signals. Moreover, oxidative mechanisms contribute to the stimulation of hepatic inflammation by directly stimulating phagocyte activation and by promoting adaptive immune responses. Finally oxidative stress favors the evolution of ALD to liver fibrosis by promoting the release of pro-fibrotic cytokines and the activation of hepatic stellate cells. Altogether these observations give a rationale to the possible clinical application of antioxidants in the therapy of ALD." @default.
- W954319650 created "2016-06-24" @default.
- W954319650 creator A5040560120 @default.
- W954319650 date "2015-01-01" @default.
- W954319650 modified "2023-09-27" @default.
- W954319650 title "Oxidative Stress in Alcoholic Liver Disease" @default.
- W954319650 cites W1514842653 @default.
- W954319650 cites W1521943312 @default.
- W954319650 cites W1528674127 @default.
- W954319650 cites W1573545768 @default.
- W954319650 cites W1599107566 @default.
- W954319650 cites W1750381543 @default.
- W954319650 cites W1827172940 @default.
- W954319650 cites W1964614394 @default.
- W954319650 cites W1965188580 @default.
- W954319650 cites W1965536826 @default.
- W954319650 cites W1967712749 @default.
- W954319650 cites W1971125395 @default.
- W954319650 cites W1971250206 @default.
- W954319650 cites W1972282906 @default.
- W954319650 cites W1973048781 @default.
- W954319650 cites W1974796362 @default.
- W954319650 cites W1975752601 @default.
- W954319650 cites W1978417777 @default.
- W954319650 cites W1978517380 @default.
- W954319650 cites W1981419458 @default.
- W954319650 cites W1982981782 @default.
- W954319650 cites W1984486531 @default.
- W954319650 cites W1984821569 @default.
- W954319650 cites W1987171553 @default.
- W954319650 cites W1987673834 @default.
- W954319650 cites W1987763288 @default.
- W954319650 cites W1988065964 @default.
- W954319650 cites W1988150327 @default.
- W954319650 cites W1990153938 @default.
- W954319650 cites W1990326789 @default.
- W954319650 cites W1990804638 @default.
- W954319650 cites W1991423707 @default.
- W954319650 cites W1994568043 @default.
- W954319650 cites W1999789764 @default.
- W954319650 cites W2000642498 @default.
- W954319650 cites W2004587487 @default.
- W954319650 cites W2004981017 @default.
- W954319650 cites W2005141055 @default.
- W954319650 cites W2005205647 @default.
- W954319650 cites W2005953918 @default.
- W954319650 cites W2006041438 @default.
- W954319650 cites W2007825238 @default.
- W954319650 cites W2012715926 @default.
- W954319650 cites W2017721030 @default.
- W954319650 cites W2020498382 @default.
- W954319650 cites W2021707548 @default.
- W954319650 cites W2022137876 @default.
- W954319650 cites W2024138646 @default.
- W954319650 cites W2025644405 @default.
- W954319650 cites W2025844537 @default.
- W954319650 cites W2028538822 @default.
- W954319650 cites W2028842093 @default.
- W954319650 cites W2029114762 @default.
- W954319650 cites W2029578496 @default.
- W954319650 cites W2030936504 @default.
- W954319650 cites W2031515050 @default.
- W954319650 cites W2032703707 @default.
- W954319650 cites W2033522281 @default.
- W954319650 cites W2033689665 @default.
- W954319650 cites W2034976767 @default.
- W954319650 cites W2035488619 @default.
- W954319650 cites W2037149610 @default.
- W954319650 cites W2037617195 @default.
- W954319650 cites W2038028850 @default.
- W954319650 cites W2039510157 @default.
- W954319650 cites W2039579730 @default.
- W954319650 cites W2041729389 @default.
- W954319650 cites W2043118364 @default.
- W954319650 cites W2049587500 @default.
- W954319650 cites W2051096835 @default.
- W954319650 cites W2051735533 @default.
- W954319650 cites W2051939090 @default.
- W954319650 cites W2052045228 @default.
- W954319650 cites W2052395914 @default.
- W954319650 cites W2054601149 @default.
- W954319650 cites W2055452745 @default.
- W954319650 cites W2060452153 @default.
- W954319650 cites W2060637877 @default.
- W954319650 cites W2061325205 @default.
- W954319650 cites W2062366543 @default.
- W954319650 cites W2064840380 @default.
- W954319650 cites W2065828665 @default.
- W954319650 cites W2066238144 @default.
- W954319650 cites W2066453798 @default.
- W954319650 cites W2066615574 @default.
- W954319650 cites W2068370659 @default.
- W954319650 cites W2068601876 @default.
- W954319650 cites W2069819211 @default.
- W954319650 cites W2071618685 @default.
- W954319650 cites W2072040022 @default.
- W954319650 cites W2072997843 @default.
- W954319650 cites W2073642561 @default.