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- W954423218 abstract "Szivizomsejtben a K+-aramok antiaritmias ''repolarizacios tartalekot'' tartanak fenn: Az IKr, IKs es IK1 akar egyikenek gatlasa sulyos proaritmias repolarizacio megnyulast okoz es letalis kamrafibrillaciohoz vezethet. - Alloxan-diabeteses kutyan az Ito es IKs csokkenese ugyanilyen hatasu, amit a Kv4.3 es Mink csatorna feherje expresszio egyidejű gatoltsaga kiser. - Szivbillyentyű atultetes celjabol hasznalt, egeszseges donor szivekből izolalt human kamrai miocitakon az IKs csokkenese szinten noveli a proaritmia es a hirtelen szivhalal rizikojat. - A K+-csatorna alegyseg expresszio mertekenek sorrendje: KvLQT1 es ERG1-nel: ember>nyul>tengerimalad, Mink-nel: tengerimalac>ember>nyul. - Az INa+/Ca2+ cserearam gatlasa kutyan antiaritmias hatasu, csokkenti az utodepolarizaciot es a triggerelt aktivitast. - A leghatekonyabb uj antiaritmikumok ''tobbszoros (tedisamil) ill. ''hibrid'' (azimilid, terikalant) ioncsatorna-gatlok. A pitvarszelektiv antiaritmias szerek hatasmodja: az IKAch, IKur es IK1 izolalt blokkolasa. - A prekondicionalas antiaritmias hatasaban kutyan a NO trigger es mediator, prosztaciklin- es szabadgyok-kepződes viszont nem vesz reszt ebben. | In the myocardial cell, there is a 'repolarization reserve' maintained by K+ currents: inhibition any of the IKr, IKs and IK1 results in severe proarrhythmic prolongation of repolarization and may cause lethal ventricular fibrillation. - The decrease of IKs and also Ito exhibits the same effect in alloxan-diabetic dogs which is accompanied by concomitant retardation of the expression of the K+ channel proteins Kv4.3 and Mink. - In undiseased human ventricular myocites obtained from donors for valve transplant surgery diminution of IKs also increases the risk of proarrhythmia and suddenc cardiac death. The extent of the order of expression of K+ channel subunits: human>rabbit>guinea pig with KvLQT1 and ERG1, and guinea pig>human>rabbit with Mink. - Inhibition of the INa+/Ca2+ exchange current is antiarrhythmic in dogs; it decreases the afterdepolarization and triggered activity. - The most efficacious new antiarrhythmics are ''multiple'' (tedisamil) or 'hybrid' (azimilid, terikalant) ion-channel blockers. - The mode of action of atrial-selective antiarrhythmics: isolated block of IKAch or IKur or IKs. - In the antiarrhythmic action of preconditioning in dogs nitrogen oxide acts as trigger and mediator, whereas formation of prostacyclin and free radicals are not involved in this effect." @default.
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- W954423218 date "2006-01-01" @default.
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- W954423218 title "Antiaritmiás és proaritmiás mechanizmusok elemzése = Analysis of antiarrhythmic and proarrhythmic mechanism" @default.
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