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- W95458628 abstract "A CHO cell line engineered to express and secrete the 75 kDa rat peptidylglycine α-amidating enzyme was adapted to serum-free medium and studied in three distinct culture systems: adherent cells in hollow fiber or microsphere fluidized bed perfusion bioreactors and suspension-adapted cells in a stirred tank bioreactor. Key parameters measured during growth and production phases included glucose and lactate concentrations, dissolved O2 and α-AE concentration. Performance parameters during 20 days of production phase with 1−2×1010 cells in each bioreactor were compared. Stirred tank fermentation of the rCHO cells provides the most efficient approach to production of reagent α-AE for use in the manufacture of amidated peptides." @default.
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- W95458628 date "1994-01-01" @default.
- W95458628 modified "2023-09-25" @default.
- W95458628 title "Comparison of Bioreactor Technologies for Efficient Production of Recombinant α-Amidating Enzyme" @default.
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- W95458628 doi "https://doi.org/10.1016/b978-0-7506-1845-8.50078-8" @default.
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